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A very high EAA release response was observed immediately after the start of the perfusion in ligated animals compared with sham\u2010operated rats. The EAA level evoked by application of the 40\u2010V tooth pulp\u2010stimulation or 1% capsaicin cream was significantly higher in the ligated animals than those in the sham\u2010operated animals. This increase of EAA level induced by capsaicin cream was inhibited by adding carboxy\u2010PTIO (100\u2003\u00b5<jats:sc>m<\/jats:sc>) to the perfusate. The applications of SNAP (2\u2003m<jats:sc>m<\/jats:sc>) into the perfusate enhanced the level of EAAs in ligated animals and sham\u2010operated animals. However, SNAP\u2010evoked EAA levels in ligated animals were not significantly different compared with those of sham\u2010operated animals. These results suggest that alterations in the stimulus\u2010evoked raised EAA levels that occur in the site of the first synaptic relay of the dental pain pathway and which are expressed via endogenous NO, and which play an important role in development and\/or maintenance of pathological pain states following dental peripheral nerve injury.<\/jats:p>","DOI":"10.1111\/j.1471-4159.2004.02768.x","type":"journal-article","created":{"date-parts":[[2004,10,15]],"date-time":"2004-10-15T08:59:32Z","timestamp":1097830772000},"page":"558-567","source":"Crossref","is-referenced-by-count":12,"title":["Nitric oxide\u2010induced increase of excitatory amino acid levels in the trigeminal nucleus caudalis of the rat with tactile hypersensitivity evoked by the loose\u2010ligation of the inferior alveolar nerves"],"prefix":"10.1111","volume":"91","author":[{"given":"Toyohiro","family":"Fujita","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinori","family":"Kamisaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norifumi","family":"Yonehara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,9,27]]},"reference":[{"key":"e_1_2_23_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)91662-4"},{"key":"e_1_2_23_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/376074a0"},{"key":"e_1_2_23_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(88)90209-6"},{"key":"e_1_2_23_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1953.16.6.634"},{"key":"e_1_2_23_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(95)11889-5"},{"key":"e_1_2_23_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.24.1.487"},{"key":"e_1_2_23_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199502000-00004"},{"key":"e_1_2_23_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(98)01299-5"},{"key":"e_1_2_23_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(81)90439-X"},{"key":"e_1_2_23_11_1","first-page":"633","article-title":"The pharmacology of excitatory and inhibitory amino acid\u2010mediated events in the transmission and modulation of pain in the spinal cord","volume":"28","author":"Dickenson A. 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