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After 15\u2003weeks on a diet, [4,5\u2010\n                    <jats:sup>3<\/jats:sup>\n                    H]docosahexaenoic acid (DHA; 22\u2003:\u20036n\u20103) was injected into the right lateral cerebral ventricle, and the rats were killed at fixed times over a period of 60\u2003days. Compared with the adequate diet, 15\u2003weeks of n\u20103 PUFA deprivation reduced plasma DHA by 89% and brain DHA by 37%; these DHA concentrations did not change thereafter. In the n\u20103 PUFA adequate rats, DHA loss half\u2010lives, calculated by plotting log\n                    <jats:sub>10<\/jats:sub>\n                    (DHA radioactivity) against time after tracer injection, equaled 33\u2003days in total brain phospholipid, 23\u2003days in phosphatidylcholine, 32\u2003days in phosphatidylethanolamine, 24\u2003days in phosphatidylinositol and 58\u2003days in phosphatidylserine; all had a decay slope significantly greater than 0 (\n                    <jats:italic>p\u2003&lt;<\/jats:italic>\n                    \u20030.05). In the n\u20103 PUFA deprived rats, these half\u2010lives were prolonged twofold or greater, and calculated rates of DHA loss from brain,\n                    <jats:italic>J<\/jats:italic>\n                    <jats:sub>\n                      <jats:italic>out<\/jats:italic>\n                    <\/jats:sub>\n                    , were reduced. Mechanisms must exist in the adult rat brain to minimize DHA metabolic loss, and to do so even more effectively in the face of reduced n\u20103 PUFA availability for only 15\u2003weeks.\n                  <\/jats:p>","DOI":"10.1111\/j.1471-4159.2004.02789.x","type":"journal-article","created":{"date-parts":[[2004,11,18]],"date-time":"2004-11-18T12:56:31Z","timestamp":1100782591000},"page":"1125-1137","source":"Crossref","is-referenced-by-count":179,"title":["Half\u2010lives of docosahexaenoic acid in rat brain phospholipids are prolonged by 15\u2003weeks of nutritional deprivation of n\u20103 polyunsaturated fatty acids"],"prefix":"10.1111","volume":"91","author":[{"suffix":"Jr","given":"James C.","family":"DeMar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaizong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane M.","family":"Bell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley I.","family":"Rapoport","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,11,18]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.3.e177"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1042\/bst0180503"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000423564"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2000.tb00066.x"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/119.12.1880"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(92)90087-C"},{"key":"e_1_2_15_8_1","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1093\/ajcn\/64.4.577","article-title":"Retroconversion and metabolism of [13C]22: 6n\u20103 in humans and rats after intake of a single dose of [13C]22: 6n\u20103\u2010triacylglycerols","volume":"64","author":"Brossard N.","year":"1996","journal-title":"Am. 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