{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T17:07:17Z","timestamp":1768583237978,"version":"3.49.0"},"reference-count":65,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T00:00:00Z","timestamp":1119398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2005,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Increased activity of plasma membrane K<jats:sup>+<\/jats:sup> channels, leading to decreased cytoplasmic K<jats:sup>+<\/jats:sup> concentrations, occurs during neuronal cell death. In the present study, we showed that the neurotoxic \u03b2\u2010amyloid peptide A\u03b2<jats:sub>25\u221235<\/jats:sub> caused a dose\u2010dependent (0.1\u201310\u2003\u00b5<jats:sc>m<\/jats:sc>) and time\u2010dependent (&gt;\u200312\u2003h) enhancement of both inactivating and non\u2010inactivating components of voltage\u2010dependent K<jats:sup>+<\/jats:sup> (VGK) currents in nerve growth factor\u2010differentiated rat phaeochromocytoma (PC\u201012) cells and primary rat hippocampal neurones. Similar effects were exerted by A\u03b2<jats:sub>1\u221242<\/jats:sub>, but not by the non\u2010neurotoxic A\u03b2<jats:sub>35\u221225<\/jats:sub> peptide. A\u03b2<jats:sub>25\u221235<\/jats:sub> and A\u03b2<jats:sub>1\u221242<\/jats:sub> caused an early (15\u201320\u2003min) increase in intracellular Ca<jats:sup>2+<\/jats:sup> concentration. This led to an increased production of reactive oxygen species (ROS), which peaked at 3\u2003h and lasted for 24\u2003h; ROS production seemed to trigger the VGK current increase as vitamin E (50\u2003\u00b5<jats:sc>m<\/jats:sc>) blocked both the A\u03b2<jats:sub>25\u221235<\/jats:sub>\u2010 and A\u03b2<jats:sub>1\u221242<\/jats:sub>\u2010induced ROS increase and VGK current enhancement. Inhibition of protein synthesis (cycloheximide, 1\u2003\u00b5g\/mL) and transcription (actinomycin D, 50\u2003ng\/mL) blocked A\u03b2<jats:sub>25\u221235<\/jats:sub>\u2010induced VGK current enhancement, suggesting that this potentiation is mediated by transcriptional activation induced by ROS. Interestingly, the specific nuclear factor\u2010\u03baB inhibitor SN\u201050 (5\u2003\u00b5<jats:sc>m<\/jats:sc>), but not its inactive analogue SN\u201050M (5\u2003\u00b5<jats:sc>m<\/jats:sc>), fully counteracted A\u03b2<jats:sub>1\u221242<\/jats:sub>\u2010 or A\u03b2<jats:sub>25\u221235<\/jats:sub>\u2010induced enhancement of VGK currents, providing evidence for a role of this family of transcription factors in regulating neuronal K<jats:sup>+<\/jats:sup> channel function during exposure to A\u03b2.<\/jats:p>","DOI":"10.1111\/j.1471-4159.2005.03075.x","type":"journal-article","created":{"date-parts":[[2005,7,15]],"date-time":"2005-07-15T16:54:18Z","timestamp":1121446458000},"page":"572-586","source":"Crossref","is-referenced-by-count":42,"title":["Nuclear factor\u2010\u03baB activation by reactive oxygen species mediates voltage\u2010gated K<sup><b>+<\/b><\/sup> current enhancement by neurotoxic \u03b2\u2010amyloid peptides in nerve growth factor\u2010differentiated PC\u201012 cells and hippocampal neurones"],"prefix":"10.1111","volume":"94","author":[{"given":"Anna","family":"Pannaccione","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnese","family":"Secondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Scorziello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaetano","family":"Cal\u00ec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Taglialatela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucio","family":"Annunziato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00207-0"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0155-04.2004"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2004.02771.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(02)00069-6"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041490309"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/0169-328X(96)00036-8","article-title":"Induction of neuroprotective kB\u2010dependent transcription by secreted forms of the Alzheimer's \u03b2\u2010amyloid precursor","volume":"40","author":"Barger S. W.","year":"1996","journal-title":"Brain Res. Mol. Brain Res."},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(02)00883-3"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(92)90837-B"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.51.32436"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)02683-X"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(01)01516-6"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1998.70051925.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.56781"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1997.293bk.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1096-4959(00)00326-2"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2004.02.006"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.12.6744"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02742436"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2990.1998.00116.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(96)10079-5"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1998.70051876.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M909563199"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(96)79570-X"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2002.00907.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.73.7.2424"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.91.1.107"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90458-8"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(96)01189-4"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2001.86.3.1312"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00134.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M302631200"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1996.271.6.C1981"},{"key":"e_1_2_7_34_1","doi-asserted-by":"crossref","first-page":"14 255","DOI":"10.1074\/jbc.270.24.14255","article-title":"Inhibition of nuclear translocation of transcription factor NF\u2010kappa B by a synthetic peptide containing a cell membrane\u2010permeable motif and nuclear localization sequence","volume":"270","author":"Lin Y. Z.","year":"1995","journal-title":"J. Biol. Chem."},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.01913.x"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-05-03840.1995"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI11916"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)00148-J"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-22-08077.2003"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-10-03303.2001"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(02)01045-6"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-05-01728.1999"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2000.84.2.1062"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00213.x"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1992.68.3.756"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1996.67041774.x"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00618.x"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1992.tb05312.x"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/369289a0"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.00391.x"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4547(20010101)63:1<20::AID-JNR3>3.0.CO;2-N"},{"key":"e_1_2_7_52_1","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1124\/mol.58.5.1115","article-title":"Pharmacological blockade of ERG K+ channels and Ca2+ influx through store\u2010operated channels exerts opposite effects on intracellular Ca2+ oscillations in pituitary GH(3) cells","volume":"58","author":"Secondo A.","year":"2000","journal-title":"Mol. Pharmacol."},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.01626.x"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.54.3.469"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.21.11698"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.54.1.113"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1997.68010265.x"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1992.0036"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-1136(200103)33:3<181::AID-GLIA1017>3.0.CO;2-Q"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(97)00053-5"},{"key":"e_1_2_7_61_1","doi-asserted-by":"crossref","first-page":"6261","DOI":"10.1523\/JNEUROSCI.18-16-06261.1998","article-title":"Potassium current development and its linkage to membrane expansion during growth of cultured embryonic mouse hippocampal neurons: sensitivity to inhibitors of phosphatidylinositol 3\u2010kinase and other protein kinases","volume":"18","author":"Wu R. L.","year":"1998","journal-title":"J. Neurosci."},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2218531"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(03)00090-X"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5335.114"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1999.0730933.x"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5412.336"}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1471-4159.2005.03075.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1471-4159.2005.03075.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T08:00:09Z","timestamp":1695801609000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1471-4159.2005.03075.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6,22]]},"references-count":65,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,8]]}},"alternative-id":["10.1111\/j.1471-4159.2005.03075.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1471-4159.2005.03075.x","archive":["Portico"],"relation":{},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,6,22]]}}}