{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T11:49:08Z","timestamp":1784375348313,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Experiments performed with Holtzman rats demonstrated that brain iron (Fe) was lower by postnatal day 13 (P13) in pups born and nursed by dams that began copper\u2010deficient (\u2013Cu) treatment at embryonic day 7. Transcardial perfusion of P24\u2013P26 males and females to remove blood Fe contamination revealed that brain Fe was still 20% lower in \u2013Cu than +Cu rats. Estimated blood content of brain for \u2013Cu rats was greater than for +Cu rats; for all groups, values ranged between 0.43 and 1.03%. Using group\u2010specific data and regression analyses, <jats:italic>r<\/jats:italic>\u2003=\u20030.99, relating blood Fe to hemoglobin, brain Fe in non\u2010perfused rats in a replicate study was lower by 33% at P13 and 39% at P24 in \u2013Cu rats. Brain extracts from these rats and from P50 rats from a post\u2010weaning model were compared by immunobloting for transferrin receptor (TfR1). P24 brain \u2013Cu\/+Cu\u2003TfR1 was 3.08, suggesting that brains of \u2013Cu rats were indeed Fe deficient. This ratio in P13 rats was 1.44, <jats:italic>p<\/jats:italic>\u2003&lt;\u20030.05. No change in P50\u2003\u2013Cu rat brain TfR1 or Fe content was detected despite a 50% reduction in plasma Fe. The results suggest that brain Fe accumulation depends on adequate Cu nutriture during perinatal development.<\/jats:p>","DOI":"10.1111\/j.1471-4159.2005.03091.x","type":"journal-article","created":{"date-parts":[[2005,4,13]],"date-time":"2005-04-13T18:47:10Z","timestamp":1113418030000},"page":"698-705","source":"Crossref","is-referenced-by-count":39,"title":["Rat brain iron concentration is lower following perinatal copper deficiency"],"prefix":"10.1111","volume":"93","author":[{"given":"Joseph R.","family":"Prohaska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna A.","family":"Gybina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.5.1468S"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.23.020102.075739"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000073507"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1937.tb04108.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.WCB.0000095800.98378.03"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/97.1.42"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/115.6.710"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1975.tb00851.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00019.2001"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200008000-00009"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/93.4.533"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020799512190"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1956.0022"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2003.12.009"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1998.71031134.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/1028415021000042811"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.7.2539"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.19.10812"},{"key":"e_1_2_7_20_1","first-page":"2658","article-title":"Chronic intake of a marginally low copper diet impairs in vitro activities of lymphocytes and neutrophils from male rats despite minimal impact on conventional indicators of copper status","volume":"125","author":"Hopkins R. G.","year":"1995","journal-title":"J. Nutr."},{"key":"e_1_2_7_21_1","first-page":"2700","article-title":"Moderate copper deprivation during gestation and lactation affects dentate gyrus and hippocampal maturation in immature male rats","volume":"125","author":"Hunt C. D.","year":"1995","journal-title":"J. Nutr."},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199601000-00008"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1306.002"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.02142.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1385\/0-89603-046-6:41"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-15-06578.2002"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/134.8.1984"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0271-5317(89)80078-8"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/153537020122600307"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/131.10.3142"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/126.3.618"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/112.9.1706"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1974.tb06920.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1975.tb06956.x"},{"key":"e_1_2_7_35_1","first-page":"1447","article-title":"Copper deficiency alters rat peptidylglycine \u03b1\u2010amidating monooxygenase activity","volume":"125","author":"Prohaska J. R.","year":"1995","journal-title":"J. Nutr."},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1994.63020709.x"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000058922.67035.D5"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.1999.tb01776.x"},{"key":"e_1_2_7_39_1","first-page":"201","article-title":"Biogenic monoamine metabolism and functional activity in iron\u2010deficient rats: behavioural correlates","volume":"51","author":"Youdim M. B.","year":"1976","journal-title":"Ciba Found Symp"}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1471-4159.2005.03091.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1471-4159.2005.03091.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/j.1471-4159.2005.03091.x","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1471-4159.2005.03091.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T05:29:26Z","timestamp":1693632566000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1471-4159.2005.03091.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,5]]}},"alternative-id":["10.1111\/j.1471-4159.2005.03091.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1471-4159.2005.03091.x","archive":["Portico"],"relation":{},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,4]]}}}