{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:40:25Z","timestamp":1787496025187,"version":"build-2736575974"},"reference-count":65,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,7,5]],"date-time":"2005-07-05T00:00:00Z","timestamp":1120521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Ethanol consumption during development affects the maturation of hippocampal circuits by mechanisms that are not fully understood. Ethanol acts as a depressant in the mature CNS and it has been assumed that this also applies to immature neurons. We investigated whether ethanol targets the neuronal network activity that is involved in the refinement of developing hippocampal synapses. This activity appears during the growth spurt period in the form of giant depolarizing potentials (GDPs). GDPs are generated by the excitatory actions of GABA and glutamate via a positive feedback circuit involving pyramidal neurons and interneurons. We found that ethanol potently increases GDP frequency in the CA3 hippocampal region of slices from neonatal rats. It also increased the frequency of GDP\u2010driven Ca\n                    <jats:sup>2+<\/jats:sup>\n                    transients in pyramidal neurons and increased the frequency of GABA\n                    <jats:sub>A<\/jats:sub>\n                    receptor\u2010mediated spontaneous postsynaptic currents in CA3 pyramidal cells and interneurons. The ethanol\u2010induced potentiation of GABAergic activity is probably the result of increased quantal GABA release at interneuronal synapses but not enhanced neuronal excitability. These findings demonstrate that ethanol is a potent stimulant of developing neuronal circuits, which might contribute to the abnormal hippocampal development associated with fetal alcohol syndrome and alcohol\u2010related neurodevelopmental disorders.\n                  <\/jats:p>","DOI":"10.1111\/j.1471-4159.2005.03294.x","type":"journal-article","created":{"date-parts":[[2005,8,25]],"date-time":"2005-08-25T06:35:05Z","timestamp":1124951705000},"page":"1500-1511","source":"Crossref","is-referenced-by-count":67,"title":["Alcohol is a potent stimulant of immature neuronal networks: implications for fetal alcohol spectrum disorder"],"prefix":"10.1111","volume":"94","author":[{"given":"Rafael","family":"Galindo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula A.","family":"Zamudio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Fernando","family":"Valenzuela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,8,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00351"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(00)01813-0"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn920"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1989.sp017762"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1063(2000)10:1<94::AID-HIPO11>3.0.CO;2-T"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80510-3"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1999.81.5.2095"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2001.tb02274.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2001.tb02129.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00316.2001"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1137276100"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0067-04.2004"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.065060"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20062"},{"key":"e_1_2_7_16_1","first-page":"1192","article-title":"Beta adrenergic sensitization of gamma\u2010aminobutyric acid receptors to ethanol involves a cyclic AMP\/protein kinase A second\u2010messenger mechanism","volume":"280","author":"Freund R. K.","year":"1997","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(01)00130-4"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.219bu.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2002.02264.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2003.11.004"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(03)00028-7"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1999.tb04045.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.9.3658"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.055137"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00997.2003"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5455.1056"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0305974101"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000017380"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1997.sp021900"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-8329(98)00043-3"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1044-7431(02)00012-X"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80265-2"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-16-06349.1998"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-0362(03)00030-8"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000106304.39174.AD"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devbrainres.2003.08.001"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1998.tb03944.x"},{"key":"e_1_2_7_38_1","first-page":"185","article-title":"Teratogenic effects of alcohol on brain and behavior","volume":"25","author":"Mattson S. N.","year":"2001","journal-title":"Alcohol Res. Health"},{"key":"e_1_2_7_39_1","first-page":"159","article-title":"Estimating the prevalence of fetal alcohol syndrome. A summary","volume":"25","author":"May P. A.","year":"2001","journal-title":"Alcohol Res. Health"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1998.00097.x"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1092550"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4886(03)00053-0"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4886(03)00051-7"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2004.01.002"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn919"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199904010-00001"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1999.82.1.202"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2002.02214.x"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0437926100"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0075-04.2004"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2002.tb02480.x"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00119.2003"},{"key":"e_1_2_7_53_1","doi-asserted-by":"crossref","first-page":"4225","DOI":"10.1523\/JNEUROSCI.21-12-04225.2001","article-title":"Strain\u2010dependent differences in calcium signaling predict excitotoxicity in murine hippocampal neurons","volume":"21","author":"Shuttleworth C. W.","year":"2001","journal-title":"J. Neurosci."},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.22.2996"},{"key":"e_1_2_7_55_1","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1523\/JNEUROSCI.17-04-01435.1997","article-title":"A pacemaker current in dye\u2010coupled hilar interneurons contributes to the generation of giant GABAergic potentials in developing hippocampus","volume":"17","author":"Strata F.","year":"1997","journal-title":"J. Neurosci."},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1063(1997)7:2<232::AID-HIPO9>3.0.CO;2-O"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2001.tb02378.x"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.10.5049"},{"key":"e_1_2_7_59_1","first-page":"153","article-title":"Alcohol\u2010related birth defects \u2013 the past, present, and future","volume":"25","author":"Warren K. R.","year":"2001","journal-title":"Alcohol Res. Health"},{"key":"e_1_2_7_60_1","first-page":"1388","article-title":"Potentiation of GABAA\u2010mediated synaptic current by ethanol in hippocampal CA1 neurons: possible role of protein kinase C","volume":"268","author":"Weiner J. L.","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)91352-8"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1997.68051949.x"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.56.1.85"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401277"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1006\/scdb.1996.0114"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00614.2002"}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1471-4159.2005.03294.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1471-4159.2005.03294.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T02:47:29Z","timestamp":1696992449000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1471-4159.2005.03294.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8,8]]},"references-count":65,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["10.1111\/j.1471-4159.2005.03294.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1471-4159.2005.03294.x","archive":["Portico"],"relation":{},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,8,8]]}}}