{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T07:53:32Z","timestamp":1768809212879,"version":"3.49.0"},"reference-count":55,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,9,12]],"date-time":"2005-09-12T00:00:00Z","timestamp":1126483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2005,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Excessive glutamate release is associated with neuronal damage. A new strategy for the treatment of neuronal injury involves inhibition of the neuropeptidase glutamate carboxypeptidase II (GCP II), also known as <jats:italic>N<\/jats:italic>\u2010acetylated \u03b1\u2010linked acidic dipeptidase. GCP II is believed to mediate the hydrolysis of <jats:italic>N<\/jats:italic>\u2010acetyl\u2010aspartyl\u2010glutamate (NAAG) to glutamate and <jats:italic>N<\/jats:italic>\u2010acetyl\u2010aspartate, and inhibition of NAAG peptidase activity (by GCP II and other peptidases) is neuroprotective. Mice were generated in which the <jats:italic>Folh1<\/jats:italic> gene encoding GCP II was disrupted (<jats:italic>Folh1\u2013\/\u2013<\/jats:italic> mice). No overt behavioral differences were apparent between <jats:italic>Folh1\u2013\/\u2013<\/jats:italic> mice and wild\u2010type littermates, with respect to their overall performance in locomotion, coordination, pain threshold, cognition and psychiatric behavioral paradigms. Morphological analysis of peripheral nerves, however, showed significantly smaller axons (reduced myelin sheaths and axon diameters) in sciatic nerves from <jats:italic>Folh1\u2013\/\u2013<\/jats:italic> mice. Following sciatic nerve crush, <jats:italic>Folh1\u2013\/\u2013<\/jats:italic> mice suffered less injury and recovered faster than wild\u2010type littermates. In a model of ischemic injury, the <jats:italic>Folh1\u2013\/\u2013<\/jats:italic> mice exhibited a significant reduction (<jats:italic>p\u2003&lt;<\/jats:italic>\u20030.05) in infarct volume compared with their wild\u2010type littermates when subjected to middle cerebral artery occlusion, a model of stroke. These findings support the hypothesis that GCP II inhibitors may represent a novel treatment for peripheral neuropathies as well as stroke.<\/jats:p>","DOI":"10.1111\/j.1471-4159.2005.03361.x","type":"journal-article","created":{"date-parts":[[2005,9,12]],"date-time":"2005-09-12T09:46:56Z","timestamp":1126518416000},"page":"314-323","source":"Crossref","is-referenced-by-count":57,"title":["Mice lacking glutamate carboxypeptidase II are protected from peripheral neuropathy and ischemic brain injury"],"prefix":"10.1111","volume":"95","author":[{"given":"Dean J.","family":"Bacich","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krystyna M.","family":"Wozniak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.\u2010C. May","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denize S.","family":"O'Keefe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noelle","family":"Callizot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Warren D. W.","family":"Heston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara S.","family":"Slusher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,9,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.21.2673"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1996.0057"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2002.01117.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1988.tb10593.x"},{"key":"e_1_2_7_6_1","first-page":"212","article-title":"Action of caffeine on the spontaneous motility of the mouse","volume":"158","author":"Boissier J. R.","year":"1965","journal-title":"Arch. Int. Pharmacodyn Ther"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(97)00531-9"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2004.02361.x"},{"key":"e_1_2_7_9_1","first-page":"2674","article-title":"Prostate\u2010specific membrane antigen is produced in tumor\u2010associated neovasculature","volume":"5","author":"Chang S. S.","year":"1999","journal-title":"Clin. Cancer Res."},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.300.2.662"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(88)90162-6"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1973.tb00097.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.3030460322"},{"key":"e_1_2_7_14_1","first-page":"385","article-title":"Synthetic analgesics: II dithienylbutenyl and dithienylbutylamines","volume":"107","author":"Eddy N. B.","year":"1953","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)61165-0"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90350-6"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1530168100"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6773(72)80203-7"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(88)90045-9"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00504983"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(00)01444-0"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00401402"},{"key":"e_1_2_7_23_1","first-page":"1807","article-title":"Expression of the prostate\u2010specific membrane antigen","volume":"54","author":"Israeli R. S.","year":"1994","journal-title":"Cancer Res."},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm0001774"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00762-7"},{"key":"e_1_2_7_26_1","first-page":"1020","article-title":"Molecular characterization of human brain N\u2010acetylated alpha\u2010linked acidic dipeptidase (NAALADase)","volume":"286","author":"Luthi\u2010Carter R.","year":"1998","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20080"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2000.tb00209.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1523\/JNEUROSCI.23-03-01041.2003","article-title":"Selective disruption of stimulus\u2010reward learning in glutamate receptor gria1 knock\u2010out mice","volume":"23","author":"Mead A. N.","year":"2003","journal-title":"J. Neurosci."},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(84)90007-4"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2000.0750443.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.10319"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2004.02358.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(97)00769-6"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300048"},{"key":"e_1_2_7_36_1","first-page":"327","article-title":"Behavioral despair in mice: a primary screening test for antidepressants","volume":"229","author":"Porsolt R. D.","year":"1977","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddh323"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4838(97)00008-3"},{"key":"e_1_2_7_39_1","first-page":"14 498","article-title":"Hydrolysis of the brain dipeptide N\u2010acetyl\u2010l\u2010aspartyl\u2010l\u2010glutamate","volume":"262","author":"Robinson M. B.","year":"1987","journal-title":"J. Biol. Chem."},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-2396(200011)38:2<161::AID-SYN7>3.0.CO;2-G"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)45359-2"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/70971"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.1056"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00429062"},{"key":"e_1_2_7_45_1","first-page":"319","article-title":"Comparative assays of antiepileptic drugs in mice and rats","volume":"106","author":"Swinyard E. A.","year":"1952","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_7_46_1","first-page":"16","article-title":"N\u2010acetylated\u2010\u03b1\u2010linked acidic dipeptidase converts N\u2010acetyl\u2010aspartyl\u2010glutamate from a neuroprotectant to a neurotoxin","volume":"295","author":"Thomas A. G.","year":"2000","journal-title":"J. Pharmacol. Exp. Ther"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(01)01198-0"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00519-7"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)90989-O"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.10263"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00393-1"},{"key":"e_1_2_7_52_1","first-page":"11","article-title":"NAALADase inhibition enhances behavioral and morphological recovery following sciatic nerve crush in mice","volume":"43","author":"Wozniak K.","year":"2000","journal-title":"Soc. Neurosci. Abstr."},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1136(199810)24:2<172::AID-GLIA2>3.0.CO;2-6"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2004.03504.x"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(01)00670-0"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2005.22.266"}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1471-4159.2005.03361.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1471-4159.2005.03361.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T13:43:56Z","timestamp":1696945436000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1471-4159.2005.03361.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9,12]]},"references-count":55,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,10]]}},"alternative-id":["10.1111\/j.1471-4159.2005.03361.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1471-4159.2005.03361.x","archive":["Portico"],"relation":{},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,9,12]]}}}