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This study was designed to evaluate the neuroprotective effects of an intranigral microinjection of serofendic acid based on behavioral, neurochemical and histochemical studies in hemi\u2010parkinsonian rats using 6\u2010hydroxydopamine (6\u2010OHDA). Rats were injected with 6\u2010OHDA in the presence or absence of serofendic acid, or were treated with serofendic acid on the same lateral side, at 12, 24 or 72\u2003h after 6\u2010OHDA lesion. Intranigral injection of 6\u2010OHDA alone induced a massive loss of tyrosine hydroxylase (TH)\u2010immunopositive neurons in the substantia nigra pars compacta (SNpc). Either simultaneous or 12\u2003h post\u2010administration of serofendic acid significantly prevented both dopaminergic neurodegeneration and drug\u2010induced rotational asymmetry. Immunoreactivities for oxidative stress markers, such as 3\u2010nitrotyrosine (3\u2010NT) and 4\u2010hydroxy\u20102\u2010nonenal (4\u2010HNE), were markedly detected in the SNpc of rats injected with 6\u2010OHDA alone. These immunoreactivities were markedly suppressed by the co\u2010administration of serofendic acid, similar to the results in vehicle\u2010treated control rats. In addition, serofendic acid inhibited 6\u2010OHDA\u2010induced \u03b1\u2010synuclein expression and glial activation in the SNpc. These results suggest that serofendic acid protects against 6\u2010OHDA\u2010induced SNpc dopaminergic neurodegeneration in a rat model of Parkinson's disease.<\/jats:p>","DOI":"10.1111\/j.1471-4159.2005.03413.x","type":"journal-article","created":{"date-parts":[[2005,8,31]],"date-time":"2005-08-31T13:41:33Z","timestamp":1125495693000},"page":"950-961","source":"Crossref","is-referenced-by-count":28,"title":["Serofendic acid prevents 6\u2010hydroxydopamine\u2010induced nigral neurodegeneration and drug\u2010induced rotational asymmetry in hemi\u2010parkinsonian rats"],"prefix":"10.1111","volume":"95","author":[{"given":"Masatoshi","family":"Inden","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihisa","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u2010ichi","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kousuke","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Yanagida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyuki","family":"Takata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiju","family":"Tsuchiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daijiro","family":"Yanagisawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaneyasu","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Taniguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Shimohama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hachiro","family":"Sugimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akinori","family":"Akaike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,8,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2003.09.013"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1997.69031196.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(01)00003-X"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/3311"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2002.7891"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/399a032"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(89)90054-3"},{"key":"e_1_2_7_9_1","first-page":"329","article-title":"Inhibition of mitochondrial complexes I and IV by 6\u2010hydroxydopamine","volume":"292","author":"Glinka Y. 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