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As age\u2010 and disease\u2010related oxidative stress is frequently associated with mitochondrial dysfunction, amphiphilic antioxidant agents of high stability and selectivity that target these organelles can provide on\u2010site protection. Such an amphiphilic nitrone protected human neuroblastoma cells at low micromolar concentrations against oxidative damage and death induced by exposure to the \u03b2\u2010amyloid peptide, hydrogen peroxide and 3\u2010hydroxykynurenine. Daily administration of the antioxidant at a concentration of only 5\u2003\u03bc<jats:sc>m<\/jats:sc> significantly increased the lifespan of the individually cultured rotifer <jats:italic>Philodina acuticornis odiosa<\/jats:italic> Milne. This compound is unique in its exceptional anti\u2010ageing efficacy, being one order of magnitude more potent than any other compound previously tested on rotifers. The nitrone protected these aquatic animals against the lethal toxicity of hydrogen peroxide and doxorubicin and greatly enhanced their survival when co\u2010administered with these oxidotoxins. These findings indicate that amphiphilic antioxidants have a great potential as neuroprotective agents in preventing the death of cells and organisms exposed to enhanced oxidative stress and damage.<\/jats:p>","DOI":"10.1111\/j.1471-4159.2005.03425.x","type":"journal-article","created":{"date-parts":[[2005,8,31]],"date-time":"2005-08-31T08:22:41Z","timestamp":1125476561000},"page":"962-973","source":"Crossref","is-referenced-by-count":35,"title":["Mitochondrial medicine: neuroprotection and life extension by the new amphiphilic nitrone LPBNAH<sup>1<\/sup> acting as a highly potent antioxidant 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