{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T22:55:51Z","timestamp":1762296951514},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,9,16]],"date-time":"2005-09-16T00:00:00Z","timestamp":1126828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Alterations of the expression of some peptidases in the pituitary gland of a fatigued rat model were identified. Rats were kept in a cage filled with water to a height of 1.5\u2003cm to disturb deep sleep. After 24\u2010h sleep disturbance, expression of neutral endopeptidase 24.11 (neprilysin) mRNA was increased in the intermediate lobe of the pituitary gland, whereas the mRNA expression of another family member, damage\u2010induced neuronal endopeptidase, which is normally expressed in a subgroup of anterior pituitary cells, was significantly suppressed. These alterations were demonstrated by RT\u2010PCR, northern blotting and <jats:italic>in situ<\/jats:italic> hybridization. Other family members, such as neprilysin\u20032 and endothelin converting enzyme\u20101, did not show any change in mRNA expression. An increase of neprilysin mRNA expression was not seen in any other tissues of the sleep\u2010disturbed rats. The enzymatic activity of neprilysin was also increased in the pituitary. The augmentation of neprilysin expression and activity was prolonged as long as the sleep disturbance continued (up to 5\u2003days), and returned to the basal level when rats were allowed to sleep freely. These results suggest that peptide processing and degradation in the pituitary may be an influential factor in fatigued states such as sleep disturbance.<\/jats:p>","DOI":"10.1111\/j.1471-4159.2005.03436.x","type":"journal-article","created":{"date-parts":[[2005,9,16]],"date-time":"2005-09-16T15:29:18Z","timestamp":1126884558000},"page":"1156-1166","source":"Crossref","is-referenced-by-count":33,"title":["Altered expression of neprilysin family members in the pituitary gland of sleep\u2010disturbed rats, an animal model of severe fatigue"],"prefix":"10.1111","volume":"95","author":[{"given":"Tokiko","family":"Ogawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumiko","family":"Kiryu\u2010Seo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Konishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhisa","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaomi","family":"Saido","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyoshi","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,9,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1994.tb16194.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00075.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1995.64041826.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1027330616073"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)91303-X"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2002-0014"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910460629"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00558.2001"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)01002-3"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-121-12-199412150-00009"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.143.5.1686"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2280119"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(97)00207-4"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)01966-6"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/72237"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1059946"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10390"},{"key":"e_1_2_7_19_1","doi-asserted-by":"crossref","first-page":"9410","DOI":"10.1523\/JNEUROSCI.22-21-09410.2002","article-title":"Damage\u2010induced neuronal endopeptidase (DINE\/ECEL) expression is regulated by leukemia inhibitory factor and deprivation of nerve growth factor in rat sensory ganglia after nerve injury","volume":"22","author":"Kato R.","year":"2002","journal-title":"J. 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