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Two hours after inducing ICH via the stereotaxic infusion of collagenase, recombinant human EPO (500 or 5000\u2003IU\/kg, ICH\u2003+\u2003EPO group) or PBS (ICH + vehicle group) was administered intraperitoneally, then once daily afterwards for 1 or 3\u2003days. ICH\u2003+\u2003EPO showed the better functional recovery in both rotarod and modified limb placing tests. The brain water content was decreased in ICH\u2003+\u2003EPO dose\u2010dependently, as compared with ICH + vehicle. The effect of EPO on the brain water content was inhibited by N(omega)\u2010Nitro\u2010L\u2010arginine methyl ester hydrochloride (L\u2010NAME, 10\u2003mg\/kg). Mean hemorrhage volume was also decreased in ICH\u2003+\u2003EPO. EPO reduced the numbers of TUNEL +, myeloperoxidase + or OX\u201042 + cells in the perihematomal area. In addition, EPO reduced the mRNA level of TNF\u2010\u03b1, Fas and Fas\u2010L, as well as the activities of caspase\u20108, 9 and 3. EPO treatment showed up\u2010regulations of endothelial nitric oxide synthase (eNOS) and p\u2010eNOS, pAkt, pSTAT3 and pERK levels. These data suggests that EPO treatment in ICH induces better functional recovery with reducing perihematomal inflammation and apoptosis, coupled with activations of eNOS, STAT3 and ERK.<\/jats:p>","DOI":"10.1111\/j.1471-4159.2006.03697.x","type":"journal-article","created":{"date-parts":[[2006,9,14]],"date-time":"2006-09-14T16:28:14Z","timestamp":1158251294000},"page":"1728-1739","source":"Crossref","is-referenced-by-count":124,"title":["Erythropoietin reduces perihematomal inflammation and cell death with eNOS and STAT3 activations in experimental intracerebral hemorrhage"],"prefix":"10.1111","volume":"96","author":[{"given":"Soon\u2010Tae","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kon","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010In","family":"Sinn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keun\u2010Hwa","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun\u2010Hee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se\u2010Jeong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong\u2010Min","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song\u2010Yi","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manho","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae\u2010Kyu","family":"Roh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,3,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)03239-0"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.19.1983"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200003000-00002"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-02-0744"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1477"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1687"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.19.10526"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0406491101"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.30.4.905"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2004.00408.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410280311"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016167228059"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.28.11.2296"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.WCB.0000130866.25040.7D"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.04.038"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.27.12.2312"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2005.03038.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/35088074"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.19.3.656"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03402029"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2004.03.009"},{"key":"e_1_2_7_23_1","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.4049\/jimmunol.163.3.1473","article-title":"Human NK cells express endothelial nitric oxide synthase, and nitric oxide protects them from activation\u2010induced cell death by regulating expression of TNF\u2010alpha","volume":"163","author":"Furuke K.","year":"1999","journal-title":"J. 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