{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:43:33Z","timestamp":1790729013496,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,3,3]],"date-time":"2006-03-03T00:00:00Z","timestamp":1141344000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The circadian clock is an autonomous biological clock that is entrainable to environmental 24\u2010h cycles by receiving time cues such as light. Generally, light given at early and late subjective night, respectively, delays and advances the phase of the circadian oscillator. We previously searched for the chicken pineal genes that are induced by light in a phase\u2010dependent manner. The present study undertook cDNA cloning and characterization of a gene whose expression was remarkably up\u2010regulated by light at late subjective night. The mRNA level of this gene exhibited robust diurnal change in the pineal gland, with a peak in the early (subjective) day under light\u2013dark cycles and constant dark condition, and hence it was designated <jats:italic>Lcg<\/jats:italic> (<jats:styled-content>L<\/jats:styled-content>ight\u2010inducible and <jats:styled-content>C<\/jats:styled-content>lock\u2010controlled <jats:styled-content>G<\/jats:styled-content>ene). Chicken <jats:italic>Lcg<\/jats:italic> encodes a coiled\u2010coil protein composed of 560 amino acid residues. Among chicken tissues, the pineal gland and the retina exhibited relatively high expression levels of LCG. LCG was colocalized with \u03b3\u2010tubulin, a centrosomal protein, when expressed in COS7 cells, and LCG is the first example of a clock\u2010related molecule being accumulated at the centrosome. Coimmunoprecipitation of LCG with \u03b3\u2010tubulin in the chicken pineal lysate suggests a link between the circadian oscillator and the centrosomal function.<\/jats:p>","DOI":"10.1111\/j.1471-4159.2006.03712.x","type":"journal-article","created":{"date-parts":[[2006,9,14]],"date-time":"2006-09-14T16:28:14Z","timestamp":1158251294000},"page":"1790-1800","source":"Crossref","is-referenced-by-count":5,"title":["<i>Lcg<\/i> is a light\u2010inducible and clock\u2010controlled gene expressed in the chicken pineal gland"],"prefix":"10.1111","volume":"96","author":[{"given":"Megumi","family":"Hatori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Okano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshito","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Doi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Fukada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,3,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02166"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M209832200"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.06.143"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(02)02276-7"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1633"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2900661"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(01)00290-3"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.10073"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-002-0570-7"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/35036078"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.01723.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2003.10.022"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jxb\/erf024"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.141090998"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.2108\/zsj.19.633"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2004.05.043"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/35089575"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80566-8"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3190761"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200212030-00016"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M506225200"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0502610102"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.2108\/zsj.21.359"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a002836"},{"key":"e_1_2_7_27_1","first-page":"619","article-title":"Cytochemical studies of mammalian tissues. I. Isolation of intact mitochondria from rat liver; some biochemical properties of mitochondria and submicroscopic particulate material","volume":"172","author":"Hogeboom G. H.","year":"1948","journal-title":"J. Biol. Chem."},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2005.01.003"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(02)00003-0"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1081\/CBI-120024211"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1086271"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.109.4.875"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.141.3.663"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(98)01336-X"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-002-0571-6"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc924"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748730404269169"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvg221"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2443.2001.00462.x"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00722-5"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/417329a"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.55.030193.000313"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature00965"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-03-00986.2000"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(99)00064-2"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/17.15.6419"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90503-7"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90390-K"},{"key":"e_1_2_7_49_1","first-page":"279","article-title":"The avian pineal, a vertebrate model system of the circadian oscillator: cellular regulation of circadian rhythms by light, second messengers, and macromolecular synthesis","volume":"45","author":"Takahashi J. S.","year":"1989","journal-title":"Recent Prog. Horm. Res."},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(05)93020-6"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/22.22.4673"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1504"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(01)02227-3"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/35088576"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90389-G"}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1471-4159.2006.03712.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1471-4159.2006.03712.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T00:52:26Z","timestamp":1696985546000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1471-4159.2006.03712.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3]]},"references-count":54,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["10.1111\/j.1471-4159.2006.03712.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1471-4159.2006.03712.x","archive":["Portico"],"relation":{},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,3]]}}}