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They evidence that ABCA2 (i) is located in intracellular vesicles, identified in transfected cells as lysosome\u2010related organelles only partially overlapping with classical endolysosomes; (ii) is a marker of neural progenitors as it is expressed in the subventricular zone of the lateral ventricle and the dentate gyrus of the hippocampal formation, sites of continual neurogenesis in the adult brain, and in nestin<jats:sup>+<\/jats:sup> cells differentiated <jats:italic>in\u2003vitro<\/jats:italic> from embryonic stem cells; (iii) persists, in the adult rodent brain, in a subset of GABAergic and glutamatergic neurons. Considering that the latter are targets of Alzheimer's lesions, these data provide a new rationale to explore the neuropathological consequences of ABCA2 functional dysregulations.<\/jats:p>","DOI":"10.1111\/j.1471-4159.2006.03714.x","type":"journal-article","created":{"date-parts":[[2006,3,15]],"date-time":"2006-03-15T13:51:54Z","timestamp":1142430714000},"page":"345-355","source":"Crossref","is-referenced-by-count":26,"title":["ABCA2 is a marker of neural progenitors and neuronal subsets in the adult rodent brain"],"prefix":"10.1111","volume":"97","author":[{"given":"Cyril","family":"Broccardo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Nieoullon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rada","family":"Amin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9rique","family":"Masmejean","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Carta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Tassi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthieu","family":"Pophillat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Rubartelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Pierres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genevi\u00e8ve","family":"Rougon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Nieoullon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gen\u00e8vieve","family":"Chazal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Chimini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,3,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M309888200"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"10\u2003463","DOI":"10.1016\/S0021-9258(18)82222-0","article-title":"Uptake and degradation of glyceraldehyde\u20103\u2010phosphate dehydrogenase by rat liver lysosomes","volume":"268","author":"Aniento F.","year":"1993","journal-title":"J. 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