{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:08:41Z","timestamp":1791443321114,"version":"4.3.3"},"reference-count":59,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,3,29]],"date-time":"2006-03-29T00:00:00Z","timestamp":1143590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recently, alterations in dopamine signaling have been implicated in Huntington's disease. In this work, dopamine release and uptake was measured in striatal slices from the R6\/2 transgenic mouse model of Huntington's disease using fast\u2010scan cyclic voltammetry at carbon\u2010fiber microelectrodes. Dopamine release in brain slices from 6\u2010week\u2010old R6\/2 mice is substantially reduced (53% of wild type), while dopamine uptake is unaffected. In agreement with this, R6\/2 mice injected with the dopamine uptake inhibitor cocaine exhibited a blunted motor activity response (54% of wild type). At 10\u2003weeks of age, an even more dramatic motor activity decrease in response to cocaine injection (21% of wild type) was observed. Moreover, the pre\u2010drug activity of 10\u2010week\u2010old R6\/2 mice was significantly reduced (by 37%) compared with 6\u2010week\u2010old R6\/2 mice. Striatal dopamine release decreased with age, indicating that progressive alterations in dopaminergic pathways may affect motor activity. The inhibition constants of cocaine and methamphetamine (METH) determined in brain slices differed little between genotype or age group, suggesting that the decreased responses to cocaine and METH arise from compromised dopamine release rather than differences in uptake or drug action. Collectively, these data demonstrate (i) a reduction in the ability of dopamine terminals to release dopamine and (ii) the importance of this attenuation of release on the motor symptoms of Huntington's disease.<\/jats:p>","DOI":"10.1111\/j.1471-4159.2006.03762.x","type":"journal-article","created":{"date-parts":[[2006,3,29]],"date-time":"2006-03-29T13:38:02Z","timestamp":1143639482000},"page":"737-746","source":"Crossref","is-referenced-by-count":114,"title":["Dopamine release is severely compromised in the R6\/2 mouse model of Huntington's disease"],"prefix":"10.1111","volume":"97","author":[{"given":"Michael A.","family":"Johnson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vignesh","family":"Rajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles E.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Mark","family":"Wightman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,3,29]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Neurochemistry in the R6\/2 Transgenic Mouse Model of Huntington's Disease.","author":"Abercrombie E. D.","year":"2002"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0893-398"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10272"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410420213"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1467-9450.00238"},{"key":"e_1_2_7_7_1","first-page":"558","volume-title":"Huntington's Disease","author":"Bates G. P.","year":"2002"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac000849y"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.120166397"},{"key":"e_1_2_7_10_1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/acps.1980.61.s280.63","article-title":"Dopamine and noradrenaline in post\u2010mortem brain in Huntington's disease and schizophrenic illness","volume":"280","author":"Bird E. D.","year":"1980","journal-title":"Acta Psychiatr. Scand. Suppl."},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi053"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.9.1753"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.01.021"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(85)90148-0"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2000.0742221.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.302.2.497"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-08-03248.1999"},{"key":"e_1_2_7_18_1","first-page":"405","volume-title":"The Biochemical Basis of Neuropharmacology","author":"Cooper J. R.","year":"2003"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0893-387"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M304615200"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(87)91506-X"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(90)90033-O"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.07-12-03915.1987"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/120.3.503"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg249"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2002.00804.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(90)90033-D"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(00)01568-X"},{"key":"e_1_2_7_29_1","first-page":"396","article-title":"Different effects of cocaine and nomifensine on dopamine uptake in the caudate\u2010putamen and nucleus accumbens","volume":"274","author":"Jones S. R.","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1995.64062581.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-06-01979.1998"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1999.0732406.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.890020511"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(92)90470-M"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2004.08.008"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg218"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.2002.1152"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81369-0"},{"key":"e_1_2_7_39_1","first-page":"1158","volume-title":"Biochemistry","author":"Mathews C. K.","year":"1996"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90239-2"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10776"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1998.78.1.189"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00059.x"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(01)00611-6"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/10.12.1243"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1006\/nbdi.2002.0534"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2005.03047.x"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92788-X"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1999.721773.x"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(84)90403-5"},{"key":"e_1_2_7_51_1","first-page":"S12","article-title":"Dopamine receptors and locomotor responses: molecular aspects","volume":"47","author":"Sealfon S. C.","year":"2000","journal-title":"Ann. Neurol."},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2005.05.008"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0893-393"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(02)00216-4"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.1089"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90585-E"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308679101"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.01704.x"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(88)90255-2"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0270(01)00459-9"}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1471-4159.2006.03762.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1471-4159.2006.03762.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T10:46:09Z","timestamp":1697021169000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1471-4159.2006.03762.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3,29]]},"references-count":59,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["10.1111\/j.1471-4159.2006.03762.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1471-4159.2006.03762.x","archive":["Portico"],"relation":{},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,3,29]]}}}