{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:56:42Z","timestamp":1791284202992,"version":"4.1.0"},"reference-count":61,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,3,15]],"date-time":"2006-03-15T00:00:00Z","timestamp":1142380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Otx2<\/jats:italic>\n                    is a vertebrate homeobox gene, which has been found to be essential for the development of rostral brain regions and appears to play a role in the development of retinal photoreceptor cells and pinealocytes. In this study, the temporal expression pattern of\n                    <jats:italic>Otx2<\/jats:italic>\n                    was revealed in the rat brain, with special emphasis on the pineal gland throughout late embryonic and postnatal stages. Widespread high expression of\n                    <jats:italic>Otx2<\/jats:italic>\n                    in the embryonic brain becomes progressively restricted in the adult to the pineal gland.\n                    <jats:italic>Crx<\/jats:italic>\n                    (\n                    <jats:italic>cone\u2013rod homeobox<\/jats:italic>\n                    ), a downstream target gene of Otx2, showed a pineal expression pattern similar to that of\n                    <jats:italic>Otx2<\/jats:italic>\n                    , although there was a distinct lag in time of onset. Otx2 protein was identified in pineal extracts and found to be localized in pinealocytes. Total pineal Otx2 mRNA did not show day\u2013night variation, nor was it influenced by removal of the sympathetic input, indicating that the level of Otx2 mRNA appears to be independent of the photoneural input to the gland. Our results are consistent with the view that pineal expression of\n                    <jats:italic>Otx2<\/jats:italic>\n                    is required for development and we hypothesize that it plays a role in the adult in controlling the expression of the cluster of genes associated with phototransduction and melatonin synthesis.\n                  <\/jats:p>","DOI":"10.1111\/j.1471-4159.2006.03773.x","type":"journal-article","created":{"date-parts":[[2006,3,15]],"date-time":"2006-03-15T08:51:54Z","timestamp":1142412714000},"page":"556-566","source":"Crossref","is-referenced-by-count":67,"title":["Expression of the\n                    <i>Otx2<\/i>\n                    homeobox gene in the developing mammalian brain: embryonic and adult expression in the pineal gland"],"prefix":"10.1111","volume":"97","author":[{"given":"Martin F.","family":"Rath","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estela","family":"Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surajit","family":"Ganguly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Morin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"M\u00f8ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,3,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.1242\/dev.121.10.3279","article-title":"Forebrain and midbrain regions are deleted in Otx2\n                  \u2013\/\u2013 mutants due to a defective anterior neuroectoderm specification during gastrulation","volume":"121","author":"Acampora D.","year":"1995","journal-title":"Development"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-0697"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.122.1.243"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2003-0439"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M412935200"},{"key":"e_1_2_7_7_1","first-page":"563","article-title":"Evolution of eyes and photoreceptor cell types","volume":"47","author":"Arendt D.","year":"2003","journal-title":"Int. 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