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The <jats:italic>src<\/jats:italic> family of tyrosine kinases are associated with the NMDAR complex and regulate NMDA channel function. Because QA is an NMDAR agonist as well as a pro\u2010oxidant agent, we investigated whether it may affect the activity of PTKs and PTPs <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic>. In synaptosomes prepared from striata dissected 15\u2003min, 30\u2003min or 15\u2003days after bilateral injection of QA we observed modulation of the phosphotyrosine pattern; a significant decrease in PTP activity; and a sustained increase in <jats:italic>c\u2010src<\/jats:italic> and <jats:italic>lyn<\/jats:italic> activity at 15 and 30\u2003min after treatment with QA, followed by a decrease 2 weeks later. Striatal synaptosomes treated <jats:italic>in vitro<\/jats:italic> with QA showed time\u2010 and dose\u2010dependent modulation of <jats:italic>c\u2010src<\/jats:italic> and <jats:italic>lyn<\/jats:italic> kinase activities. Moreover, the nitric oxide synthase inhibitor <jats:italic>N<\/jats:italic><jats:sup>G<\/jats:sup>\u2010nitro\u2010<jats:sc>l<\/jats:sc>\u2010arginine\u2010methyl ester, the NMDAR antagonist <jats:sc>d<\/jats:sc>\u20102\u2010amino\u20105\u2010phosphonovaleric acid and pyruvate suppressed the QA\u2010induced modulation of <jats:italic>c\u2010src<\/jats:italic> activity. These findings suggest a novel feature of QA in regulating <jats:italic>src<\/jats:italic> kinase activity through the formation of reactive radical species and\/or NMDAR overactivation.<\/jats:p>","DOI":"10.1111\/j.1471-4159.2006.03814.x","type":"journal-article","created":{"date-parts":[[2006,4,21]],"date-time":"2006-04-21T20:34:56Z","timestamp":1145651696000},"page":"1327-1336","source":"Crossref","is-referenced-by-count":13,"title":["Quinolinic acid modulates the activity of <i>src<\/i> family kinases in rat striatum: <i>in vivo<\/i> and <i>in vitro<\/i> studies"],"prefix":"10.1111","volume":"97","author":[{"given":"Alessio","family":"Metere","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Mallozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Minetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rosaria","family":"Domenici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"P\u00e8zzola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Popoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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