{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:34:22Z","timestamp":1790768062587,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,4,25]],"date-time":"2006-04-25T00:00:00Z","timestamp":1145923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>1\u2010Methyl\u20104\u2010phenyl\u20101,2,3,6\u2010tetrahydropyridine (MPTP)\u2010induced neurotoxicity is one of the experimental models most commonly used to study the pathogenesis of Parkinson's disease (PD). Although the biochemical mechanisms underlying the cell death induced by MPTP remain to be clarified, it has been found that the mitochondrial apoptotic signaling pathway plays an important role in the neurotoxicity of MPTP. Nucling is a novel type of apoptosis\u2010associated molecule, essential for cytochrome\u2003<jats:italic>c<\/jats:italic>, apoptosis protease activating factor\u20031 (Apaf\u20101), pro\u2010caspase\u20109 apoptosome induction and caspase\u20109 activation following pro\u2010apoptotic stress. Here we found that Nucling\u2010deficient mice treated with MPTP did not exhibit locomotor dysfunction in an open\u2010field test. The substantia nigra dopaminergic neurons of Nucling\u2010deficient mice were resistant to the damaging effects of the neurotoxin MPTP. Up\u2010regulated expression of apoptosome was attenuated in Nucling\u2010deficient mice treated with MPTP. These results indicate an important role for Nucling in MPTP\u2010induced neuronal degeneration and suggest that the suppression of Nucling would be of therapeutic benefit for the treatment of neurodegeneration in PD.<\/jats:p>","DOI":"10.1111\/j.1471-4159.2006.03833.x","type":"journal-article","created":{"date-parts":[[2006,4,25]],"date-time":"2006-04-25T17:14:39Z","timestamp":1145985279000},"page":"1126-1135","source":"Crossref","is-referenced-by-count":13,"title":["Attenuation of MPTP\u2010induced neurotoxicity and locomotor dysfunction in Nucling\u2010deficient mice via suppression of the apoptosome pathway"],"prefix":"10.1111","volume":"97","author":[{"given":"Xichuan","family":"Teng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rika","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuji","family":"Kaji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Fukui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,4,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1090940210"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(00)01584-8"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4439(98)00083-0"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81732-8"},{"key":"e_1_2_7_6_1","first-page":"548","article-title":"Neurochemical and behavioral effects of 1\u2010methyl\u20104\u2010phenyl\u20101,2,3,6\u2010tetrahydropyridine (MPTP) in rat, guinea pig and monkey","volume":"20","author":"Chiueh C. 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