{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:34:15Z","timestamp":1762144455308,"version":"3.32.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,5,12]],"date-time":"2006-05-12T00:00:00Z","timestamp":1147392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Parietal and occipital cortices, while densely innervated by noradrenalin 2 (NA) projections, possess a comparatively sparse dopamine 2 (DA) innervation, even sparser than the prefrontal cortex. We previously reported that reboxetine and desipramine, two selective norepinephrine transporter (NET) blockers, at doses that maximally increase DA in the prefrontal cortex, do not increase DA in the parietal and occipital cortices. In the present study, we performed a full dose\u2013response study of the effect of systemic reboxetine and desipramine on DA and NA in dialysates from the parietal and occipital cortices. Seven doses of reboxetine (0.1, 0.25, 0.5, 1.0, 2.5, 5.0 and 10\u2003mg\/kg) and four doses of desipramine (0.25, 1.0, 2.5 and 5.0\u2003mg\/kg) were tested. Reboxetine and desipramine differentially affected dialysate DA as compared with NA. Reboxetine increased DA maximally by about 100% after doses of 0.25\u20130.5\u2003mg\/kg and showed a bell\u2010shaped dose\u2013response function in both areas; desipramine did not affect DA in the parietal cortex and increased it in the occipital cortex only at 2.5\u2003mg\/kg. NA was maximally increased by 275% by 0.5\u20132.5\u2003mg\/kg reboxetine and by about 300% by 5.0\u2003mg\/kg desipramine with a more linear dose\u2013response curve. The mechanism of peculiar dose\u2013response function of dialysate DA after reboxetine and desipramine was further investigated by testing the effect of drugs on dialysate DA and NA under \u03b1<jats:sub>2<\/jats:sub>receptor blockade. Under local perfusion of the occipital cortex with idazoxan, an otherwise ineffective dose of reboxetine and desipramine (5\u2003mg\/kg) became effective in raising extracellular DA. In contrast, the effect of reboxetine on NA was potentiated, while that of desipramine was not affected. These results suggest that, in the parietal and occipital cortices, extracellular NA, raised by NET blockade, exerts a preferential inhibitory influence on DA release by acting on local \u03b1<jats:sub>2<\/jats:sub>receptors, thus accounting for the bell\u2010shaped feature of the dose\u2013response function of drugs on dialysate DA in these areas.<\/jats:p>","DOI":"10.1111\/j.1471-4159.2006.03851.x","type":"journal-article","created":{"date-parts":[[2006,5,12]],"date-time":"2006-05-12T12:30:01Z","timestamp":1147437001000},"page":"113-121","source":"Crossref","is-referenced-by-count":13,"title":["Differential \u03b1<sub>2<\/sub>\u2010mediated inhibition of dopamine and noradrenaline release in the parietal and occipital cortex following noradrenaline transporter blockade"],"prefix":"10.1111","volume":"98","author":[{"given":"V.","family":"Valentini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Cacciapaglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Frau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Di Chiara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,5,30]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"13","article-title":"Histochemical identification and localization of dopaminergic axons in rat and human cerebral cortex","volume":"16","author":"Berger B.","year":"1977","journal-title":"Adv. Biochem. Psychopharmacol."},{"key":"e_1_2_6_3_1","first-page":"525","article-title":"Dopaminergic innervation of the frontal cerebral cortex. Evolutionary trends and functional implications","volume":"57","author":"Berger B.","year":"1992","journal-title":"Adv. Neurol."},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00531-0"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-001-0986-x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1990.tb04599.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.02239.x"},{"key":"e_1_2_6_8_1","first-page":"231S","article-title":"Heterologous monoamine re\u2010uptake: lack of transmitter specificity of neuron\u2010specific carriers","volume":"20","author":"Di Chiara G.","year":"1992","journal-title":"Neurochem. Int."},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02244939"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1997.68031326.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1997.69062616.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1995.65010111.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5437.105"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(99)00175-2"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(02)00377-9"},{"key":"e_1_2_6_16_1","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/S0022-3565(24)29568-9","article-title":"Reboxetine modulates the firing pattern of dopamine cells in the ventral tegmental area and selectively increases dopamine availability in the prefrontal cortex","volume":"297","author":"Linner L.","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2004.07.038"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(98)00078-1"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2000.00982.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-02-00389.2002"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00554.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M209532200"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2004.03.002"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1994.63010195.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00484.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1998.00135.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02244785"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02246048"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02246169"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.02238.x"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2005.03030.x"}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1471-4159.2006.03851.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1471-4159.2006.03851.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T23:12:31Z","timestamp":1736377951000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1471-4159.2006.03851.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5,30]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["10.1111\/j.1471-4159.2006.03851.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1471-4159.2006.03851.x","archive":["Portico"],"relation":{},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"type":"print","value":"0022-3042"},{"type":"electronic","value":"1471-4159"}],"subject":[],"published":{"date-parts":[[2006,5,30]]}}}