{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T14:45:57Z","timestamp":1789397157850,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The modulation of cell proliferation in neural progenitor cells (NPCs) is believed to play a role in neuronal regeneration. Recent studies showed that K<jats:sup>+<\/jats:sup> channel activity influenced cell proliferation. Therefore, we examined NPCs for K<jats:sup>+<\/jats:sup> channels and tested whether NPC self renewing can be modulated by synthetic K<jats:sup>+<\/jats:sup> channel modulators. The whole\u2010cell K<jats:sup>+<\/jats:sup> current was partly K<jats:sup>+<\/jats:sup> dependent and showed a cumulative inactivating component. Two tetra\u2010ethyl\u2010ammonium ion (TEA)\u2010sensitve K<jats:sup>+<\/jats:sup> currents with different voltage dependencies (<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/JNC_3967_mu1.gif\" xlink:title=\"inline image\"\/>\u2003= 65\u2003\u03bc<jats:sc>m<\/jats:sc>, E<jats:sub>50<\/jats:sub>\u2003=\u2003\u22120.3\u2003\u00b1\u20031.3\u2003mV and <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/JNC_3967_mu2.gif\" xlink:title=\"inline image\"\/>\u2003=\u20038\u2003m<jats:sc>m<\/jats:sc>, E<jats:sub>50<\/jats:sub>\u2003= \u221215.2\u2003\u00b1\u20032.8\u2003mV) and an almost TEA\u2010insensitive current were identified. Kaliotoxin blocked approximately 50% of the entire K<jats:sup>+<\/jats:sup> currents (IC<jats:sub>50<\/jats:sub>\u2003=\u20030.25\u2003n<jats:sc>m<\/jats:sc>). These properties resembled functional characteristics of K<jats:sub>v<\/jats:sub>1.4, K<jats:sub>v<\/jats:sub>1.3 and K<jats:sub>v<\/jats:sub>3.1 channels. Transcripts for these channels, as well as proteins for K<jats:sub>v<\/jats:sub>1.3 and K<jats:sub>v<\/jats:sub>3.1, were identified. Immunocytochemical staining revealed K<jats:sub>v<\/jats:sub>1.3 and K<jats:sub>v<\/jats:sub>3.1 K<jats:sup>+<\/jats:sup> channel expression in almost all NPCs. The blockage of K<jats:sub>v<\/jats:sub>3.1 by low concentrations of TEA, as well as the blockage of K<jats:sub>v<\/jats:sub>1.3 by Psora\u20104, increased NPC proliferation. These findings underline the regulatory role of K<jats:sup>+<\/jats:sup> channels on the cell cycle and imply that K<jats:sup>+<\/jats:sup> channel modulators might be used therapeutically to activate endogenous NPCs.<\/jats:p>","DOI":"10.1111\/j.1471-4159.2006.03967.x","type":"journal-article","created":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T13:43:34Z","timestamp":1153143814000},"page":"426-437","source":"Crossref","is-referenced-by-count":54,"title":["Selective blockage of K<sub>v<\/sub>1.3 and K<sub>v<\/sub>3.1 channels increases neural progenitor cell proliferation"],"prefix":"10.1111","volume":"99","author":[{"given":"Stefan","family":"Liebau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Pr\u00f6pper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"B\u00f6ckers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Lehmann\u2010Horn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Storch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Grissmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver H.","family":"Wittekindt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-21-08234.1997"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.241497298"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.104.008193"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.110.5.601"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-08-02659.1996"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004240050449"},{"key":"e_1_2_7_8_1","first-page":"1227","article-title":"Pharmacological characterization of five cloned voltage\u2010gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines","volume":"45","author":"Grissmer S.","year":"1994","journal-title":"Mol. 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