{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T07:47:56Z","timestamp":1778744876683,"version":"3.51.4"},"reference-count":97,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,5]],"date-time":"2006-07-05T00:00:00Z","timestamp":1152057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We evaluated whether both inert and catalytically active metalloporphyrin antioxidants,<jats:italic>meso<\/jats:italic>\u2010substituted with either phenyl\u2010based or<jats:italic>N<\/jats:italic>\u2010alkylpyridinium\u2010based groups, suppress Ca<jats:sup>2+<\/jats:sup>\u2010dependent neurotoxicity in cell culture models of relevance to cerebral ischemia. Representatives from both metalloporphyrin classes, regardless of antioxidant strength, protected cultured cortical neurons or PC\u201012 cultures against the Ca<jats:sup>2+<\/jats:sup>ionophores ionomycin or A23187, by suppressing neurotoxic Ca<jats:sup>2+<\/jats:sup>influx. Some metalloporphyrins suppressed excitotoxic Ca<jats:sup>2+<\/jats:sup>influx indirectly induced by the Ca<jats:sup>2+<\/jats:sup>ionophores in cortical neurons. Metalloporphyrins did not quench intracellular fluorescence, suggesting localization to the plasma membrane interface and\/or interference with Ca<jats:sup>2+<\/jats:sup>ionophores. Metalloporphyrins suppressed ionomycin\u2010induced Mn<jats:sup>2+<\/jats:sup>influx, but did not protect cortical neurons against pyrithione, a Zn<jats:sup>2+<\/jats:sup>ionophore. In other Ca<jats:sup>2+<\/jats:sup>\u2010dependent paradigms, Ca<jats:sup>2+<\/jats:sup>influx via plasma membrane depolarization, but not through reversal of plasmalemmal Na<jats:sup>+<\/jats:sup>\/Ca<jats:sup>2+<\/jats:sup>exchangers, was modestly suppressed by Mn<jats:sup>III<\/jats:sup><jats:italic>meso<\/jats:italic>\u2010tetrakis(4\u2010benzoic acid)porphyrin (Mn<jats:sup>III<\/jats:sup>TBAP) or by an inert analog, Zn<jats:sup>II<\/jats:sup>TBAP. Mn<jats:sup>III<\/jats:sup>TBAP and Zn<jats:sup>II<\/jats:sup>TBAP potently protected cortical neurons against long\u2010duration oxygen\u2013glucose deprivation (OGD), performed in the presence of antagonists of NMDA, \u03b1\u2010amino\u20103\u2010hydroxy\u20105\u2010methylisoxazole\u20104\u2010propionate and L\u2010type voltage\u2010gated Ca<jats:sup>2+<\/jats:sup>channels, raising the possibility of an unconventional mode of blockade of transient receptor protein melastatin 7 channels by a metalloTBAP family of metalloporphyrins. The present study extends the range of Ca<jats:sup>2+<\/jats:sup>\u2010dependent insults for which metalloporphyrins demonstrate unconventional neuroprotection. MetalloTBAPs appear capable of targeting an OGD temporal continuum.<\/jats:p>","DOI":"10.1111\/j.1471-4159.2006.03973.x","type":"journal-article","created":{"date-parts":[[2006,7,7]],"date-time":"2006-07-07T02:18:04Z","timestamp":1152238684000},"page":"1324-1342","source":"Crossref","is-referenced-by-count":9,"title":["Unconventional neuroprotection against Ca<sup>2+<\/sup>\u2010dependent insults by metalloporphyrin catalytic antioxidants"],"prefix":"10.1111","volume":"98","author":[{"given":"Joseph S.","family":"Tauskela","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Brunette","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lech","family":"Kiedrowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karine","family":"Lortie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Hewitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Morley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)01017-1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(87)90843-2"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0143-4160(02)00203-8"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)91268-8"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1163\/156856203322553419"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic990118k"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2004.04.041"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/b400818a"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/b513761f"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(02)03953-X"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(02)01008-0"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.06.065"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(03)00171-0"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2004.02984.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00070-0"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7400243"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490350513"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1999.1414"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20552"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2002.01227.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6446(04)03139-3"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfi108"},{"key":"e_1_2_7_24_1","first-page":"1227","article-title":"A metalloporphyrin superoxide dismutase mimetic protects against paraquat\u2010induced endothelial cell injury, in vitro","volume":"275","author":"Day B. J.","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1997.0341"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(98)00261-5"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1006\/nbdi.2000.0303"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-10-06377.1995"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1996.66030951.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi961391q"},{"key":"e_1_2_7_31_1","doi-asserted-by":"crossref","first-page":"19\u2003630","DOI":"10.1016\/S0021-9258(19)47160-3","article-title":"Effect of membrane potential on divalent cation transport catalyzed by the \u2018electroneutral\u2019 ionophores A23187 and ionomycin","volume":"264","author":"Fasolato C.","year":"1989","journal-title":"J. Biol. Chem."},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M213302200"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0896(02)00153-0"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(95)00232-8"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00508-9"},{"key":"e_1_2_7_36_1","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1006\/bbrc.1996.1538","article-title":"A role of peroxides in Ca2+ ionophore\u2010induced apoptosis in cultured rat cortical neurons","volume":"227","author":"Hatanaka Y.","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"e_1_2_7_37_1","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1096\/fj.02-1086fje","article-title":"Inhibition of glutamate release by delaying ATP fall accounts for neuroprotective effects of antioxidants in experimental stroke","volume":"17","author":"Hurtado O.","year":"2003","journal-title":"FASEB J."},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0162-0134(03)00135-1"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2003.08.036"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)90214-G"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1006\/taap.2001.9144"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.039123"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0162-0134(02)00455-5"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2002.00810.x"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.3109\/00207459609000616"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200409150-00023"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2004.02462.x"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(81)84738-8"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(02)00989-9"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm021060d"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1997.69020524.x"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)00195-9"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000190001.97140.cf"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2005.07.001"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00457.x"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1999.79.4.1431"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)34550-7"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)90233-X"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-13-04582.2001"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)91003-J"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20059"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0298-159"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1013818719932"},{"key":"e_1_2_7_64_1","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/S0022-3565(24)39264-X","article-title":"Preferential inhibition by a novel Na+\/Ca2+ channel blocker NS\u20107 of severe to mild hypoxic injury in rat cerebrocortical slices: a possible involvement of a highly voltage\u2010dependent blockade of Ca2+ channel","volume":"293","author":"Oka M.","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2004.04.040"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)00056-V"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)90850-8"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(99)01336-X"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80052-5"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(84)90545-7"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)02320-3"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.53.4.795"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2003.11.001"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/1011-1344(95)07155-U"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1986.tb03579.x"},{"key":"e_1_2_7_76_1","first-page":"883","article-title":"Selective neurotoxicity induced by the ionophore lasalocid in rat dissociated cerebral cultures, involvement of the NMDA receptor\/channel","volume":"17","author":"Safran N.","year":"1996","journal-title":"Neurotoxicology"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-9551-6_15"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1998.71062349.x"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.386513"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.2174\/1566524043479211"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2004.101.4.0669"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1358\/dnp.2002.15.10.740236"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(02)00979-6"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1996.tb34445.x"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/0143-4160(89)90066-3"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M211346200"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00424a027"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(03)01371-2"},{"key":"e_1_2_7_89_1","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1096\/fj.05-3795fje","article-title":"An alternative Ca2+\u2010dependent mechanism of neuroprotection by the metalloporphyrin class of superoxide dismutase mimetics","volume":"19","author":"Tauskela J. S.","year":"2005","journal-title":"FASEB J."},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2006.03.046"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705811"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2003.07.004"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0896(03)00272-4"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2003.10.029"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.01639.x"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(98)00236-7"},{"key":"e_1_2_7_97_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp049936v"},{"key":"e_1_2_7_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/0730-725X(95)02103-Z"}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1471-4159.2006.03973.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1471-4159.2006.03973.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T20:21:50Z","timestamp":1736454110000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1471-4159.2006.03973.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7,5]]},"references-count":97,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["10.1111\/j.1471-4159.2006.03973.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1471-4159.2006.03973.x","archive":["Portico"],"relation":{},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7,5]]}}}