{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:38:09Z","timestamp":1790987889699,"version":"4.1.0"},"reference-count":67,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We have previously shown that neonatal administration of (+\/\u2013)3,4\u2010methylenedioxymethamphetamine and (+)fenfluramine produce deficits in spatial and path integration learning, whereas (+)methamphetamine causes deficits in spatial learning. Conversely, cocaine and (+\/\u2013)methylphenidate have no effect on either form of learning following neonatal administration. The purpose of the present study was to determine whether corticosterone and\/or monoamine levels were changed following subcutaneous administration of 10\u2003mg\/kg (+)methamphetamine, (+\/\u2013)3,4\u2010methylenedioxymethamphetamine, (+)fenfluramine, (+\/\u2013)methylphenidate or cocaine every 2\u2003h (total of four injections) on postnatal day 11. Twenty\u2010four hours after the first dose, plasma, striatum and hippocampus were collected. Corticosterone levels were increased in methamphetamine\u2010, fenfluramine\u2010, methylenedioxymethamphetamine\u2010 and methylphenidate\u2010treated rats relative to levels in saline\u2010treated rats, whereas cocaine\u2010treated rats were unaffected. In the striatum and hippocampus, serotonin and 5\u2010hydroxyindolacetic acid were reduced in animals treated with methylenedioxymethamphetamine or fenfluramine, compared with levels in saline controls. Dopamine levels were not changed by any of the drugs, although 3,4\u2010dihydroxyphenylacetic acid was decreased following methylenedioxymethamphetamine or methamphetamine. Minimal effects were seen in neurotransmitter levels following injection of cocaine or methylphenidate. These data suggest that drugs that affect corticosterone and hippocampal serotonin are associated with both spatial learning and path integration deficits, and those that affect corticosterone and 3,4\u2010dihydroxyphenylacetic acid are associated with spatial learning deficits only.<\/jats:p>","DOI":"10.1111\/j.1471-4159.2006.04034.x","type":"journal-article","created":{"date-parts":[[2006,8,8]],"date-time":"2006-08-08T17:42:50Z","timestamp":1155058970000},"page":"1369-1378","source":"Crossref","is-referenced-by-count":35,"title":["Comparison of monoamine and corticosterone levels 24\u2003h following (+)methamphetamine, (+\/\u2013)3,4\u2010methylenedioxymethamphetamine, cocaine, (+)fenfluramine or (+\/\u2013)methylphenidate administration in the neonatal rat"],"prefix":"10.1111","volume":"98","author":[{"given":"Tori L.","family":"Schaefer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa A.","family":"Ehrman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary A.","family":"Gudelsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles V.","family":"Vorhees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"83","article-title":"Timetables of neurogenesis in the human brain based on experimentally determined patterns in the rat","volume":"14","author":"Bayer S. L.","year":"1993","journal-title":"Neurol. Toxicol."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1985.tb10946.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s007020170101"},{"key":"e_1_2_7_5_1","first-page":"285","article-title":"Age modulates the long\u2010term but not the acute effects of the serotonergic neurotoxicant 3,4\u2010methylenedioxymethamphetamine","volume":"271","author":"Broening H. W.","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_7_6_1","first-page":"325","article-title":"Age\u2010dependent sensitivity of rats to the long\u2010term effects of the serotonergic neurotoxicant (+\/\u2013)\u20103,4\u2010methylenedioxymethamphetamine (MDMA) correlates with the magnitude of the MDMA\u2010induced thermal response","volume":"275","author":"Broening H. W.","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-09-03228.2001"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/sper.2001.29038"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000069362"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(97)81791-9"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)02107-7"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1996.tb13993.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2004.06.004"},{"key":"e_1_2_7_14_1","first-page":"228","article-title":"Methamphetamine abuse during pregnancy and its health impact on neonates born at Siriraj Hospital, Bangkok, Thailand","volume":"35","author":"Chomchai C.","year":"2004","journal-title":"Southeast Asian J. Trop. Med. Public Health"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.20166"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01271184"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1993.02160340048012"},{"key":"e_1_2_7_18_1","volume-title":"Annual Report 2004: The state of the Drugs Problem in the European Union and Norway.","author":"EMCDDA","year":"2004"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-108X(199301)13:1<41::AID-EAT2260130106>3.0.CO;2-L"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(00)00042-4"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/00221309.1974.9920794"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903130309"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-0362(01)00178-7"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0892-0362(92)90020-B"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)02985-2"},{"key":"e_1_2_7_26_1","volume-title":"Monitoring the Future National Survey Results on Drug Abuse, 1975\u20132003","author":"Johnston L. D.","year":"2004"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.10023"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199809103391101"},{"key":"e_1_2_7_29_1","volume-title":"Experimental Design: Procedures for the Behavioral Science","author":"Kirk R. E.","year":"1995"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(01)00464-6"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(03)00219-0"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(93)90162-F"},{"key":"e_1_2_7_33_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1159\/000112549","article-title":"Serotonin as a differentiation signal in early neurogenesis","volume":"1","author":"Lauder J. M.","year":"1978","journal-title":"Dev. Neurosci."},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.420240803"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4886(03)00207-3"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(03)00173-5"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)00297-7"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2002.02100.x"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2002.02100.x"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1358\/dot.2003.39.7.799442"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s007020200010"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2005.02.001"},{"key":"e_1_2_7_43_1","doi-asserted-by":"crossref","unstructured":"O'CallaghanJ. P.andMillerD. B.(2002)Neurotoxic effects of substituted amphetamines in rats and mice inHandbood of Neurotoxicology(MassaroE. J. ed.) Vol.2 pp.269\u2013301.Humana Press Inc. Totowa.","DOI":"10.1385\/1-59259-165-5:269"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.420080108"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4530(93)90042-J"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8545(05)70361-2"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.104.2.e18"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-2396(20010101)39:1<32::AID-SYN5>3.0.CO;2-3"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(86)90011-0"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0173(86)90010-X"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004703-200302000-00006"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4530(98)00029-8"},{"key":"e_1_2_7_53_1","doi-asserted-by":"crossref","first-page":"4732","DOI":"10.1523\/JNEUROSCI.20-12-04732.2000","article-title":"Adult learning deficits after neonatal exposure to d\u2010methamphetamine: selective effects on spatial navigation and memory","volume":"20","author":"Vorhees C. V.","year":"2000","journal-title":"J. Neurosci."},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-0362(99)00071-9"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2004.06.003"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.20379"},{"key":"e_1_2_7_57_1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0166-4328(96)00071-X","article-title":"Serotonin as a developmental signal","volume":"73","author":"Whitaker\u2010Azmitia P. M.","year":"1996","journal-title":"Behav. Brain Res."},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-0362(00)00091-X"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)03620-X"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devbrainres.2003.11.001"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-003-1433-y"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)04278-6"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.10159"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0953-816X.2004.03405.x"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0953-816X.2004.03405.x"},{"key":"e_1_2_7_66_1","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1146\/annurev.ps.29.020178.003243","article-title":"Statistics and data analysis: trading bias for reduced mean squared error","volume":"29","author":"Winer B. J.","year":"1978","journal-title":"Annu. Rev. Psychol."},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)90778-A"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(96)00176-9"}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1471-4159.2006.04034.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1471-4159.2006.04034.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T19:56:39Z","timestamp":1697399799000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1471-4159.2006.04034.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7,20]]},"references-count":67,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.1111\/j.1471-4159.2006.04034.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1471-4159.2006.04034.x","archive":["Portico"],"relation":{},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7,20]]}}}