{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:16:22Z","timestamp":1777464982770,"version":"3.51.4"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recent prevalence of acquired forms of transmissible spongiform encephalopathies (TSEs) has urged the development of early diagnostic measures as well as therapeutic interventions. To extend our previous findings on the value of amyloid imaging probes for these purposes, styrylbenzoazole derivatives with better permeability of blood\u2013brain barrier (BBB) were developed and analyzed in this study. The new styrylbenzoazole compounds clearly labeled prion protein (PrP) plaques in brain specimens from human TSE in a manner irrespective of pathogen strain, and a representative compound BF\u2010168 detected abnormal PrP aggregates in the brain of TSE\u2010infected mice when the probe was injected intravenously. On the other hand, most of the compounds inhibited abnormal PrP formation in TSE\u2010infected cells with IC<jats:sub>50<\/jats:sub> values in the nanomolar range, indicating that they represent one of the most potent classes of inhibitor ever reported. BF\u2010168 prolonged the lives of mice infected intracerebrally with TSE when the compound was given intravenously at the preclinical stage. The new compounds, however, failed to detect synaptic PrP deposition and to show pathogen\u2010independent therapeutic efficacy, similar to the amyloid imaging probes we previously reported. The compounds were BBB permeable and non\u2010toxic at doses for imaging and treatment; therefore, they are expected to be of practical use in human TSE.<\/jats:p>","DOI":"10.1111\/j.1471-4159.2006.04035.x","type":"journal-article","created":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T13:43:34Z","timestamp":1153143814000},"page":"198-205","source":"Crossref","is-referenced-by-count":29,"title":["Styrylbenzoazole derivatives for imaging of prion plaques and treatment of transmissible spongiform encephalopathies"],"prefix":"10.1111","volume":"99","author":[{"given":"Kensuke","family":"Ishikawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukitsuka","family":"Kudo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyuki","family":"Nishida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Suemoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tohru","family":"Sawada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Iwaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsumi","family":"Doh\u2010ura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"8029","DOI":"10.1523\/JNEUROSCI.23-22-08029.2003","article-title":"Molecular\u2010imaging probe 2\u2010(1\u2010[6\u2010[(2\u2010fluoroethyl)(methyl) amino]\u20102\u2010naphthyl]ethylidene) malononitrile labels prion plaques in vitro","volume":"23","author":"Bresjanac M.","year":"2003","journal-title":"J. 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