{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T13:03:10Z","timestamp":1789736590910,"version":"4.0.1"},"reference-count":57,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,8,8]],"date-time":"2006-08-08T00:00:00Z","timestamp":1154995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    CCAAT\/enhancer binding protein \u03b2 (C\/EBP\u03b2) is a leucine\u2010zipper transcription factor that regulates cell growth and differentiation in mammals. Expression of many pro\u2010inflammatory genes including the cytokine interleukin\u20106 is known to be controlled by C\/EBP\u03b2. We report that focal cerebral ischemia induced by transient middle cerebral artery occlusion (MCAO) significantly increases\n                    <jats:italic>C\/EBP\u03b2<\/jats:italic>\n                    gene expression in mouse brain at between 6 and 72\u2003h of reperfusion. To understand the functional significance of C\/EBP\u03b2 in postischemic inflammation and brain damage, we induced transient MCAO in cohorts of adult\n                    <jats:italic>C\/EBP\u03b2<\/jats:italic>\n                    null mice and their wild\u2010type littermates. At 3\u2003days of reperfusion following transient MCAO,\n                    <jats:italic>C\/EBP\u03b2<\/jats:italic>\n                    null mice showed significantly smaller infarcts, reduced neurological deficits, decreased terminal deoxynucleotidyl transferase\u2010mediated dUTP nick\u2010end labeling\u2010positive cells, decreased intercellular adhesion molecule 1 (ICAM1) immunopositive vessels, decreased extravasated neutrophils and fewer activated microglia\/macrophages, compared with their wild\u2010type littermates. Furthermore, GeneChip analysis showed that postischemic induction of many transcripts known to promote inflammation and neuronal damage was less pronounced in the brains of\n                    <jats:italic>C\/EBP\u03b2<\/jats:italic>\n                    \u2013\/\u2013 mice compared with\n                    <jats:italic>C\/EBP\u03b2<\/jats:italic>\n                    +\/+ mice. These results suggest a significant role for C\/EBP\u03b2 in postischemic inflammation and brain damage.\n                  <\/jats:p>","DOI":"10.1111\/j.1471-4159.2006.04056.x","type":"journal-article","created":{"date-parts":[[2006,8,8]],"date-time":"2006-08-08T11:31:58Z","timestamp":1155036718000},"page":"1718-1731","source":"Crossref","is-referenced-by-count":101,"title":["Decreased brain damage and curtailed inflammation in transcription factor CCAAT\/enhancer binding protein \u03b2 knockout mice following transient focal cerebral ischemia"],"prefix":"10.1111","volume":"98","author":[{"given":"Ramya","family":"Kapadia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kudret","family":"Tureyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kellie K.","family":"Bowen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haviryaji","family":"Kalluri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter F.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghu","family":"Vemuganti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,8,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1990.tb08316.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20242"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1999.00845.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200204000-00003"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200209000-00004"},{"key":"e_1_2_7_7_1","first-page":"97.1","article-title":"Egr1 null mice show curtailed inflammatory gene expression and significant neuroprotection following transient focal ischemia","volume":"31","author":"Bowen K. K.","year":"2005","journal-title":"Soc. Neurosci. Abstr."},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.14.4841-4858.2003"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.18.12.7269"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200105000-00009"},{"key":"e_1_2_7_11_1","first-page":"557","article-title":"Ischemia\u2010induced neuronal apoptosis","volume":"36","author":"Choi D. W.","year":"1996","journal-title":"Curr. Opin. Neurobiol."},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M313253200"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-005-1413-7"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2004.02316.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2005.25.297"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200007000-00008"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-200102000-00014"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.4.719"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1995.5"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2000.00252.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(94)00138-E"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.1.84"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.WCB.0000062340.80057.06"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20218"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.WCB.0000123141.67811.91"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(01)00017-1"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(03)00521-5"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.25.1.202"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1996.tb01556.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90459-R"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1006\/clim.1999.4723"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2005.03508.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M413661200"},{"key":"e_1_2_7_34_1","first-page":"440.11","article-title":"JAK2\u2013STAT3 activation promotes and SOCS3 induction decreases focal ischemia\u2010induced neuronal damage","volume":"31","author":"Satriotomo I.","year":"2005","journal-title":"Soc. Neurosci. Abstr."},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1159\/000090293"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(03)00255-9"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/rr27"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00626.x"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2000.tb00248.x"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200003000-00017"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.11.17.2153"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cr.7290346"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1990.47"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401365"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(00)00289-X"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1033.2000.01778.x"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2004.101.5.0799"},{"key":"e_1_2_7_48_1","first-page":"194","article-title":"Ideal suture diameter is critical for consistent middle cerebral artery occlusion in mice","volume":"56","author":"Tureyen K.","year":"2005","journal-title":"J. Neurosurg."},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.08.058"},{"key":"e_1_2_7_50_1","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1097\/00004647-200108000-00007","article-title":"Ornithine decarboxylase knockdown exacerbates transient focal ischemia\u2010induced neuronal damage in rat brain","volume":"21","author":"Vemuganti R.","year":"2001","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2002.01208.x"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10486"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000106479.53235.3E"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200301000-00008"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/82168"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-0693"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600004"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.2174\/1566524033479717"}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1471-4159.2006.04056.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1471-4159.2006.04056.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T06:40:32Z","timestamp":1697352032000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1471-4159.2006.04056.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,8]]},"references-count":57,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.1111\/j.1471-4159.2006.04056.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1471-4159.2006.04056.x","archive":["Portico"],"relation":{},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8,8]]}}}