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We identified protein kinase D (PKD) as one of the earliest markers of neuronal DNA damage. Phosphorylation of the PKD\u2010activation domain could be detected within 15\u2003min of genotoxic stress and was concurrent with ataxia telangiectasia\u2010mutated (ATM) activation. PKD stimulation was selective to DNA damage and did not occur with other stress stimuli examined. <jats:italic>In vivo<\/jats:italic>, both young and adult rats showed increased levels of phosphorylated PKD in neuronal tissues after injection of DNA\u2010toxin etoposide. These results indicate that PKD activation is an early neuronal response to DNA damage, suggesting that signaling downstream of PKD may be critical for neuronal survival after genotoxic stress.<\/jats:p>","DOI":"10.1111\/j.1471-4159.2006.04116.x","type":"journal-article","created":{"date-parts":[[2006,8,14]],"date-time":"2006-08-14T10:45:16Z","timestamp":1155552316000},"page":"218-225","source":"Crossref","is-referenced-by-count":13,"title":["The activation loop phosphorylation of protein kinase D is an early marker of neuronal DNA damage"],"prefix":"10.1111","volume":"99","author":[{"given":"Cagri G.","family":"Besirli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Eugene M.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,8,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01368"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M300742200"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401259"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M205299200"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M106083200"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10437"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.01749.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C100466200"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80671-6"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80587-5"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.2.5.509"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2004.03.024"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(02)00019-2"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(99)01503-9"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1289"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M005261200"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80606-6"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(83)03022-0"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19811215)48:12<2577::AID-CNCR2820481207>3.0.CO;2-Z"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(01)00163-7"},{"key":"e_1_2_7_22_1","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1523\/JNEUROSCI.10-01-00184.1990","article-title":"Cytosine arabinoside kills postmitotic neurons in a fashion resembling trophic factor deprivation: evidence that a deoxycytidine\u2010dependent process may be required for nerve growth factor signal transduction","volume":"10","author":"Martin D. 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