{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:16:38Z","timestamp":1765545398092},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,8,14]],"date-time":"2006-08-14T00:00:00Z","timestamp":1155513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effects of pH<jats:sub>i<\/jats:sub> on GABAergic miniature inhibitory postsynaptic currents (mIPSCs) were studied in mechanically dissociated CA3 pyramidal neurons, by use of ammonium prepulse and whole\u2010cell patch\u2010clamp techniques, under the voltage\u2010clamp condition. NH<jats:sub>4<\/jats:sub>Cl itself, which is expected to alkalinize pH<jats:sub>i<\/jats:sub>, increased GABAergic mIPSC frequency in a concentration\u2010dependent manner. In contrast, NH<jats:sub>4<\/jats:sub>Cl decreased mIPSC frequency, either in the presence of 200\u2003\u00b5<jats:sc>m<\/jats:sc> Cd<jats:sup>2+<\/jats:sup> or in Ca<jats:sup>2+<\/jats:sup>\u2010free external solution, suggesting that intraterminal alkalosis decreased GABAergic mIPSC frequency while [NH4<jats:sup>+<\/jats:sup>] itself may activate Ca<jats:sup>2+<\/jats:sup> channels by depolarizing the terminal. On the other hand, GABAergic mIPSC frequency was greatly increased immediately after NH<jats:sub>4<\/jats:sub>Cl removal, a condition expected to acidify pH<jats:sub>i<\/jats:sub>, and recovered to the control level within 2\u2003min after NH<jats:sub>4<\/jats:sub>Cl removal. This explosive increase in mIPSC frequency observed after NH<jats:sub>4<\/jats:sub>Cl removal was completely eliminated after depletion of Ca<jats:sup>2+<\/jats:sup> stores with 1\u2003\u00b5<jats:sc>m<\/jats:sc> thapsigargin in the Ca<jats:sup>2+<\/jats:sup>\u2010free external solution, suggesting that acidification increases in intraterminal Ca<jats:sup>2+<\/jats:sup> concentration via both extracellular Ca<jats:sup>2+<\/jats:sup> influx and Ca<jats:sup>2+<\/jats:sup> release from the stores. However, the acidification\u2010induced increase in mIPSC frequency had not recovered by 10\u2003min after NH<jats:sub>4<\/jats:sub>Cl removal either in the Na<jats:sup>+<\/jats:sup>\u2010free external solution or in the presence of 10\u2003\u00b5<jats:sc>m<\/jats:sc> 5\u2010(<jats:italic>N<\/jats:italic>\u2010ethyl\u2010<jats:italic>N<\/jats:italic>\u2010isopropyl)\u2010amiloride (EIPA), a specific Na<jats:sup>+<\/jats:sup>\/H<jats:sup>+<\/jats:sup> exchanger (NHE) blocker. The present results suggest that NHEs are major intraterminal pH regulators on GABAergic presynaptic nerve terminals, and that the NHE\u2010mediated regulation of pH<jats:sub>i<\/jats:sub> under normal physiological or pathological conditions might play an important role in the neuronal excitability by increasing inhibitory tones.<\/jats:p>","DOI":"10.1111\/j.1471-4159.2006.04168.x","type":"journal-article","created":{"date-parts":[[2006,10,3]],"date-time":"2006-10-03T15:09:58Z","timestamp":1159888198000},"page":"1224-1236","source":"Crossref","is-referenced-by-count":32,"title":["The Na<sup>+<\/sup>\/H<sup>+<\/sup> exchanger is a major pH regulator in GABAergic presynaptic nerve terminals synapsing onto rat CA3 pyramidal neurons"],"prefix":"10.1111","volume":"99","author":[{"given":"Il\u2010Sung","family":"Jang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malcolm S.","family":"Brodwick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi\u2010Ming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo\u2010Jin","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung\u2010Ju","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norio","family":"Akaike","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,8,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2170\/jjphysiol.44.433"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(02)00010-X"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021396"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021494"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)01687-X"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1992.262.4.C803"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.041bu.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-08-02982.1998"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00010.2003"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(95)00039-9"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.91.2.305"},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1523\/JNEUROSCI.18-08-02944.1998","article-title":"The role of an subtype M2\u2013M3 His in regulating inhibition of GABAA receptor current by zinc and other divalent cations","volume":"18","author":"Fisher J. 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