{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T15:13:54Z","timestamp":1790954034336,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,8,23]],"date-time":"2006-08-23T00:00:00Z","timestamp":1156291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The central dopamine system plays significant roles in motor activity and drug\u2010induced behavioural sensitization. Our goal was to determine the significance of dopamine D<jats:sub>3<\/jats:sub> receptors in the development of behavioural sensitization to methamphetamine, assessed with D<jats:sub>3<\/jats:sub> receptor mutant mice. The absence of D<jats:sub>3<\/jats:sub> receptors significantly increased the behavioural responses to acute methamphetamine and evoked a faster rate of behavioural sensitization to chronic methamphetamine. In addition, both D<jats:sub>3<\/jats:sub> receptor protein and mRNA levels in the limbic forebrain decreased in sensitized wild\u2010type mice. Further analyses indicated that D<jats:sub>1<\/jats:sub>\u2010dependent behavioural sensitization and the number of limbic D<jats:sub>1<\/jats:sub> receptors increased in sensitized D<jats:sub>3<\/jats:sub> mutants as compared with sensitized wild\u2010type mice. Consistent with this finding, we observed higher levels of D<jats:sub>1<\/jats:sub> receptor\u2010evoked cAMP accumulation and basal phosphoDARPP\u201032\/Thr34 in the limbic forebrain of D<jats:sub>3<\/jats:sub> mutants than wild\u2010type mice and the difference was more pronounced after chronic methamphetamine treatment. We also observed an increase in phospho\u2010extracellular signal\u2010regulated kinase\u20032 but a decrease in phosphoAkt\/Ser473 and phosphoglycogen synthase kinase\u20033 (GSK3)\u2010\u03b1\/\u03b2 in the limbic forebrain of D<jats:sub>3<\/jats:sub> mutants compared with wild\u2010type mice after methamphetamine treatment. The convergent results implicate D<jats:sub>3<\/jats:sub> receptors as a negative regulator of the development of methamphetamine sensitization. A compensatory up\u2010regulation of D<jats:sub>1<\/jats:sub> receptor\u2010mediated signals, in addition to an altered Akt\/GSK3 pathway, could contribute to the accelerated development of behavioural sensitization.<\/jats:p>","DOI":"10.1111\/j.1471-4159.2006.04203.x","type":"journal-article","created":{"date-parts":[[2006,11,20]],"date-time":"2006-11-20T15:04:16Z","timestamp":1164035056000},"page":"225-241","source":"Crossref","is-referenced-by-count":39,"title":["Dual alteration of limbic dopamine D<sub>1<\/sub> receptor\u2010mediated signalling and the Akt\/GSK3 pathway in dopamine D<sub>3<\/sub> receptor mutants during the development of methamphetamine sensitization"],"prefix":"10.1111","volume":"100","author":[{"given":"Pei\u2010Chun","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chu\u2010Lan","family":"Lao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Chung","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,8,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.5.1945"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.09.005"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(00)00179-2"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.10232"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)00524-9"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(03)02522-8"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(96)01438-2"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.40.24329"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(96)00300-7"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.294.5544.1024"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1060028"},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","first-page":"6287","DOI":"10.1523\/JNEUROSCI.15-09-06287.1995","article-title":"The persistence of behavioral sensitization to cocaine parallels enhanced inhibition of nucleus accumbens neurons","volume":"15","author":"Henry D. 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