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GABA<jats:sub>A<\/jats:sub> receptors also represent a major site of action of clinically relevant drugs, such as benzodiazepines, barbiturates, ethanol, and general anesthetics. It has been shown that the intracellular M3\u2010M4 loop of GABA<jats:sub>A<\/jats:sub> receptors plays an important role in regulating GABA<jats:sub>A<\/jats:sub> receptor function. Therefore, studies of the function of receptor intracellular loop associated proteins become important for understanding mechanisms of regulating receptor activity. Recently, several labs have used the yeast two\u2010hybrid assay to identify proteins interacting with GABA<jats:sub>A<\/jats:sub> receptors, for example, the interaction of GABA<jats:sub>A<\/jats:sub> receptor associated protein (GABARAP) and Golgi\u2010specific DHHC zinc finger protein (GODZ) with \u03b3 subunits, PRIP, phospholipase C\u2010related, catalytically inactive proteins (PRIP\u20101) and (PRIP\u20102) with GABARAP and receptor \u03b32 and \u03b2 subunits, Plic\u20101 with some \u03b1 and \u03b2 subunits, radixin with the \u03b15 subunit, HAP1 with the \u03b21 subunit, GABA<jats:sub>A<\/jats:sub> receptor interacting factor\u20101 (GRIF\u20101) with the \u03b22 subunit, and brefeldin A\u2010inhibited GDP\/GTP exchange factor 2 (BIG2) with the \u03b23 subunit. These proteins have been shown to play important roles in modulating the activities of GABA<jats:sub>A<\/jats:sub> receptors ranging from enhancing trafficking, to stabilizing surface and internalized receptors, to regulating modification of GABA<jats:sub>A<\/jats:sub> receptors. This article reviews the current studies of GABA<jats:sub>A<\/jats:sub> receptor intracellular loop\u2010associated proteins.<\/jats:p>","DOI":"10.1111\/j.1471-4159.2006.04206.x","type":"journal-article","created":{"date-parts":[[2006,11,3]],"date-time":"2006-11-03T00:15:26Z","timestamp":1162512926000},"page":"279-294","source":"Crossref","is-referenced-by-count":161,"title":["GABA<sub>A<\/sub> receptor associated proteins: a key factor regulating GABA<sub>A<\/sub> receptor function"],"prefix":"10.1111","volume":"100","author":[{"given":"Zi\u2010Wei","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard W.","family":"Olsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,8,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M313470200"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.10.6775"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/embo-reports\/kvf026"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.24.13069-13076.2002"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M200438200"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn0901-908"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-23-08643.2000"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3751-05.2005"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(99)00171-9"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M409095200"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7716512"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M405786200"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2004.02481.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.104.004200"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M509805200"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.190133497"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00558-X"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1044-7431(03)00069-1"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/386279a0"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-16-06930.1999"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddh328"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4889(03)00086-7"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/6.13.2205"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/2798"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M312806200"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/340245a0"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(03)00037-8"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.06.018"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(02)02655-8"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-19-07674.1998"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.2.840"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.20136"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M308762200"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5479.563"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(96)30015-7"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(94)00778-0"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/35044114"},{"key":"e_1_2_11_39_1","doi-asserted-by":"crossref","first-page":"10\u2003469","DOI":"10.1523\/JNEUROSCI.2267-05.2005","article-title":"Gephyrin regulates the cell surface dynamics of synaptic GABAA receptors","volume":"25","author":"Jacob T. 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