{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:26:31Z","timestamp":1793226391124,"version":"4.5.0"},"reference-count":64,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,10,2]],"date-time":"2006-10-02T00:00:00Z","timestamp":1159747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Leptin\u2010responsive neurons of the hypothalamus constitute a heterogeneous population expressing a vast array of different neuropeptides and neurotransmitters, some of which participate in the regulation of hunger and satiety. Here we report that somatostatin modulates the efficacy of leptin\u2010signalling in the rat hypothalamus. Using a two\u2010pulse paradigm at 30\u2010min intervals, we delivered somatostatin or somatostatin receptor subtype\u2010selective agonists in combination with leptin into the lateral cerebral ventricle of stereotaxically cannulated rats. To monitor the effect of somatostatin on the leptin\u2010signalling pathway, we quantified changes in the leptin\u2010mediated activation of STAT3, the signal transducer and activator of transcription 3. Successive administration of somatostatin and leptin diminished the level of STAT3\u2010phosphorylation and nuclear STAT3 translocation in the ventromedial and dorsomedial hypothalamic nuclei, the lateral hypothalamic area, and the arcuate nucleus by about 40% compared to leptin administration alone. Furthermore, application of subtype\u2010selective somatostatin receptor agonists suggests that the observed reduction in leptin\u2010responsiveness is predominantly mediated by the sst3 receptor\u2010subtype, followed by sst1 and sst2. In addition, the intensity of the negative\u2010regulatory effect of somatostatin on leptin\u2010signalling displayed regional differences for the three receptor\u2010subtypes involved. Addressing the functional consequences of the diminished leptin\u2010signalling, behavioural analyses showed that centrally applied somatostatin counteracts the leptin\u2010mediated suppression of food intake. These results suggest that the pleiotropic effector somatostatin also plays a role in the central regulation of energy homeostasis.<\/jats:p>","DOI":"10.1111\/j.1471-4159.2006.04219.x","type":"journal-article","created":{"date-parts":[[2006,11,3]],"date-time":"2006-11-03T00:15:26Z","timestamp":1162512926000},"page":"468-478","source":"Crossref","is-referenced-by-count":27,"title":["Somatostatin, a negative\u2010regulator of central leptin action in the rat hypothalamus"],"prefix":"10.1111","volume":"100","author":[{"given":"Z.","family":"Stepanyan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kocharyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Behrens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Koebnick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Pyrski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Meyerhof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,10,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.19.14563"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.47.4.538"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.51.32686"},{"key":"e_1_2_7_5_1","first-page":"CR685","article-title":"Serum leptin levels in acromegaly \u2013 a significant role for adipose tissue and fasting insulin\/glucose ratio","volume":"8","author":"Bolanowski M.","year":"2002","journal-title":"Med. Sci. Monit."},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)03322-4"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.179.4068.77"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(96)90072-4"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-0115(83)90014-9"},{"key":"e_1_2_7_10_1","first-page":"2S13","article-title":"[Regulation of cell proliferation by somatostatin]","volume":"63","author":"Buscail L.","year":"2002","journal-title":"Ann. Endocrinol (Paris)"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1620095"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/35078085"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2002-221090"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(00)00299-6"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5332.1630"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.12.4139"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.138.2.5033"},{"key":"e_1_2_7_18_1","first-page":"25","article-title":"The neurobiology of somatostatin","volume":"8","author":"Epelbaum J.","year":"1994","journal-title":"Crit. Rev. Neurobiol."},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)91600-L"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0149-7634(94)90055-8"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E03-02-0069"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200501190-00008"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/mend.11.4.9907"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.13.6231"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.02.001"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-01-00559.1998"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7624777"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00354-6"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M210767200"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2002-220077"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-07-02413.2001"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)02912-7"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(90)90022-A"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(93)90179-S"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M304524200"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2000.84.3.1464"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/379632a0"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.17.9677"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(96)00473-5"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-0726"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2004.02402.x"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1006\/frne.1999.0183"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.135.6.7988476"},{"key":"e_1_2_7_44_1","unstructured":"PaxinosG.andWatsonC.(1986)The rat brain in stereotaxic coordinates.Academic Press 2nd edition San Diego CA USA."},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(02)00012-1"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7624776"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M006084200"},{"key":"e_1_2_7_48_1","doi-asserted-by":"crossref","first-page":"5641","DOI":"10.1210\/endo.138.12.5713","article-title":"Leptin inhibits in vitro hypothalamic somatostatin secretion and somatostatin mRNA levels","volume":"138","author":"Quintela M.","year":"1997","journal-title":"Endocrinology"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.250483897"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5389.737"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.139.2.5909"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1159\/000054348"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-10-03785.2000"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1998.00386.x"},{"key":"e_1_2_7_55_1","first-page":"1865","article-title":"Immunohistochemical determination of five somatostatin receptors in meningioma reveals frequent overexpression of somatostatin receptor subtype sst2A","volume":"6","author":"Schulz S.","year":"2000","journal-title":"Clin. Cancer Res."},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118891"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(98)00082-2"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-0115(02)00152-0"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.2003.01077.x"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2001.01180.x"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M313522200"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.7.4065"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(02)00148-X"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/372425a0"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1006\/smim.2000.0223"}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1471-4159.2006.04219.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1471-4159.2006.04219.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T19:34:41Z","timestamp":1697052881000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1471-4159.2006.04219.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,2]]},"references-count":64,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["10.1111\/j.1471-4159.2006.04219.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1471-4159.2006.04219.x","archive":["Portico"],"relation":{},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,2]]}}}