{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:40:05Z","timestamp":1790980805301,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T00:00:00Z","timestamp":1160006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Desferrioxamine inhibits cortical necrosis in neonatal rats with experimental pneumococcal meningitis, suggesting that iron\u2010induced oxidative damage might be responsible for neuronal damage. We therefore examined the spatial and temporal profile of changes in cortical iron and iron homeostatic proteins during pneumococcal meningitis. Infection was associated with a steady and global increase of non\u2010haem iron in the cortex, particularly in neuronal cell bodies of layer II and V, and in capillary endothelial cells. The non\u2010haem iron increase was associated with induction of haem oxygenase (HO)\u20101 in neurones, microglia and capillary endothelial cells, whereas HO\u20102 levels remained unchanged, suggesting that the non\u2010haem iron increase might be the result of HO\u20101\u2010mediated haem degradation. Indeed, treatment with the haem oxygenase inhibitor tin protoporphyrin (which completely blocked the accumulation of bilirubin detected in HO\u20101\u2010positive cells) completely prevented the infection\u2010associated non\u2010haem iron increase. The same cells also displayed markedly increased ferritin staining, the increase of which occurred independently of HO activity. At the same time, no increase in DNA\/RNA oxidation was observed in infected animals (as assessed by\n                    <jats:italic>in situ<\/jats:italic>\n                    detection of 8\u2010hydroxy[deoxy]guanosine), strongly suggesting that ferritin up\u2010regulation protected the brain from iron\u2010induced oxidative damage. Thus, although pneumococcal meningitis leads to an increase of cortical non\u2010haem iron, protective mechanisms up\u2010regulated in parallel prevent iron\u2010induced oxidative damage. Cortical damage does not appear to be a direct consequence of increased iron, therefore.\n                  <\/jats:p>","DOI":"10.1111\/j.1471-4159.2006.04230.x","type":"journal-article","created":{"date-parts":[[2006,11,20]],"date-time":"2006-11-20T12:17:40Z","timestamp":1164025060000},"page":"532-544","source":"Crossref","is-referenced-by-count":17,"title":["Induction of haem oxygenase\u20101 causes cortical non\u2010haem iron increase in experimental pneumococcal meningitis: evidence that concomitant ferritin up\u2010regulation prevents iron\u2010induced oxidative damage"],"prefix":"10.1111","volume":"100","author":[{"given":"Hao","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen L.","family":"Leib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna M.","family":"Ferriero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin G.","family":"T\u00e4uber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Christen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,10,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/315658"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"18\u2003148","DOI":"10.1016\/S0021-9258(19)37165-0","article-title":"Ferritin: a cytoprotective antioxidant strategem of endothelium","volume":"267","author":"Balla G.","year":"1992","journal-title":"J. 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