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Understanding the molecular mechanisms underlying the neural plasticity deficits in these devastating conditions may lead the way toward new therapeutic targets, both disease\u2010specific and more generalized, which can ameliorate degenerative cognitive deficits. Furthermore, investigations of \u2018pathological plasticity\u2019 in these diseases lend insight into normal brain function. This review will present evidence for altered plasticity in Huntington's and Alzheimer's diseases, relate these findings to symptomatology, and review possible causes and commonalities.<\/jats:p>","DOI":"10.1111\/j.1471-4159.2006.04275.x","type":"journal-article","created":{"date-parts":[[2007,1,8]],"date-time":"2007-01-08T15:05:54Z","timestamp":1168268754000},"page":"874-882","source":"Crossref","is-referenced-by-count":26,"title":["Molecular mechanisms mediating pathological plasticity in Huntington's disease and Alzheimer's disease"],"prefix":"10.1111","volume":"100","author":[{"given":"Tara L.","family":"Spires","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony J.","family":"Hannan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,10,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(00)00516-9"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10048-004-0198-8"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02998"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.3.631"},{"key":"e_1_2_7_6_1","volume-title":"Huntington's Disease","author":"Bates G.","year":"2002"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0511256103"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00308809"},{"key":"e_1_2_7_9_1","first-page":"89","article-title":"Neurofibrillary tangles of Alzheimer's disease: an immunohistochemical study","volume":"17","author":"Brion J. 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