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In this study, a short\u2010term course of lovastatin treatment is shown to markedly inhibit the development of experimental autoimmune neuritis (EAN) in the absence of hepatotoxic or myotoxic complications. Independent of cholesterol reduction, lovastatin treatment prevented EAN\u2010induced peripheral nerve conduction deficits and morphologic nerve injury. Co\u2010administration with mevalonate neutralized the prophylactic effects of lovastatin. When administered therapeutically, lovastatin significantly shortened the disease course. Autoreactive immunity, measured <jats:italic>in vitro<\/jats:italic> by myelin\u2010stimulated proliferation of splenocytes, was significantly diminished by <jats:italic>in vivo<\/jats:italic> lovastatin treatment. Th1\u2010dominant immune responses, measured by cytokine profiling, however, were not affected by lovastatin. Sciatic nerves of lovastatin\u2010treated immunized rats showed markedly reduced levels of cellular infiltrates. Treating peripheral nerve endothelial monolayers with lovastatin significantly inhibited the <jats:italic>in vitro<\/jats:italic> migration of autoreactive splenocytes. Together, these data demonstrate that a short\u2010term course of lovastatin attenuates the development and progression of EAN in Lewis rats by limiting the proliferation and migration of autoreactive leukocytes.<\/jats:p>","DOI":"10.1111\/j.1471-4159.2006.04309.x","type":"journal-article","created":{"date-parts":[[2006,12,22]],"date-time":"2006-12-22T05:19:45Z","timestamp":1166764785000},"page":"1265-1277","source":"Crossref","is-referenced-by-count":40,"title":["Lovastatin attenuates nerve injury in an animal model of Guillain\u2013Barr\u00e9 syndrome"],"prefix":"10.1111","volume":"100","author":[{"given":"Jason P.","family":"Sarkey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Richards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Evan B.","family":"Stubbs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,11,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-003-1201-9"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021425"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.1.64"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.1994.1051"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20395"},{"key":"e_1_2_7_7_1","first-page":"755","article-title":"Metabolism and excretion studies in mouse after single and multiple oral doses of the 3\u2010hydroxy\u20103\u2010methylglutaryl\u2010CoA reductase inhibitor atorvastatin","volume":"26","author":"Black A. 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