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In this study we show that (R,S)3,5\u2010dihydroxyphenylglycine (DHPG; 6 and 60\u2003nmol ICV), a selective group I mGlu receptor agonist, raised extracellular dopamine respectively by 176% and 243% of basal values in the medial prefrontal cortex as assessed by<jats:italic>in vivo<\/jats:italic>microdialysis in conscious rats. (R,S)2\u2010chloro\u20105\u2010hydroxyphenylglycine (60\u2003nmol ICV), a selective mGlu5 receptor agonist, raised extracellular dopamine by 396% of basal values. Intra\u2010VTA DHPG (0.6\u20136\u2003nmol) mimicked ICV injection whereas intracortical infusion (1\u20131000\u2003\u00b5mol\/L) had no effect. DHPG\u2010induced rise of extracellular dopamine was reversed by tetrodotoxin and by the selective mGlu1 and mGlu5 receptor antagonists 7(hydroxyimino)cyclopropa[b]chromen\u20101a\u2010carboxylate (CPCCOEt) and 2\u2010methyl\u20106\u2010(phenylethynyl)pyridine (MPEP) either ICV or into the ventrotegmental area (VTA), suggesting that neuronal release and both mGlu1 and mGlu5 receptors were involved. These results support the existence of functional mGlu1 and mGlu5 receptors in the VTA regulating the release of dopamine in the medial prefrontal cortex.<\/jats:p>","DOI":"10.1111\/j.1471-4159.2006.04317.x","type":"journal-article","created":{"date-parts":[[2006,12,15]],"date-time":"2006-12-15T00:56:29Z","timestamp":1166144189000},"page":"1658-1666","source":"Crossref","is-referenced-by-count":17,"title":["Stimulation of group I mGlu receptors in the ventrotegmental area enhances extracellular dopamine in the rat medial prefrontal cortex"],"prefix":"10.1111","volume":"100","author":[{"given":"G.","family":"Renoldi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Calcagno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Borsini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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