{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:10:54Z","timestamp":1791310254137,"version":"4.3.1"},"reference-count":71,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,11,9]],"date-time":"2006-11-09T00:00:00Z","timestamp":1163030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The neurochemical profile of the striatum of R6\/2 Huntington\u2019s disease mice was examined at different stages of pathogenesis using\n                    <jats:italic>in\u00a0vivo<\/jats:italic>\n                    <jats:sup>1<\/jats:sup>\n                    H NMR spectroscopy at 9.4\u2003T. Between 8 and 12\u2003weeks, R6\/2 mice exhibited distinct changes in a set of 17 quantifiable metabolites compared with littermate controls. Concentrations of creatine, glycerophosphorylcholine, glutamine and glutathione increased and\n                    <jats:italic>N<\/jats:italic>\n                    \u2010acetylaspartate decreased at 8\u2003weeks. By 12\u2003weeks, concentrations of phosphocreatine, taurine, ascorbate, glutamate, and\n                    <jats:italic>myo<\/jats:italic>\n                    \u2010inositol increased and phophorylethanolamine decreased. These metabolic changes probably reflected multiple processes, including compensatory processes to maintain homeostasis, active at different stages in the development of HD. The observed changes in concentrations suggested impairment of neurotransmission, neuronal integrity and energy demand, and increased membrane breakdown, gliosis, and osmotic and oxidative stress. Comparisons between metabolite concentrations from individual animals clearly distinguished HD transgenics from non\u2010diseased littermates and identified possible markers of disease progression. Metabolic changes in R6\/2 striata were distinctly different from those observed previously in the quinolinic acid and 3NP models of HD. Longitudinal monitoring of changes in these metabolites may provide quantifiable measures of disease progression and treatment effects in both mouse models of HD and patients.\n                  <\/jats:p>","DOI":"10.1111\/j.1471-4159.2006.04323.x","type":"journal-article","created":{"date-parts":[[2007,1,8]],"date-time":"2007-01-08T10:05:54Z","timestamp":1168250754000},"page":"1397-1406","source":"Crossref","is-referenced-by-count":108,"title":["Neurochemical changes in Huntington R6\/2 mouse striatum detected by\n                    <i>in\u00a0vivo<\/i>\n                    <sup>1<\/sup>\n                    H NMR spectroscopy"],"prefix":"10.1111","volume":"100","author":[{"given":"Ivan","family":"Tkac","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet M.","family":"Dubinsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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