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Here, we examined whether exposure to a novel environment, a mild psychological stressor, would affect the number of phospho\u2010acetylated histone H3\u2010positive [P(Ser10)\u2010Ac(Lys14)\u2010H3<jats:sup>+<\/jats:sup>] neurons in the rat hippocampus. We show that: (i) the stressful situation induced a marked increase in the number of P(Ser10)\u2010Ac(Lys14)\u2010H3<jats:sup>+<\/jats:sup> neurons, specifically in the dentate gyrus; (ii) the stress\u2010induced rise in P(Ser10)\u2010Ac(Lys14)\u2010H3<jats:sup>+<\/jats:sup> neurons occurred in the dentate gyrus throughout the rostro\u2010caudal axis of the hippocampus, but they were exclusively located in the middle and superficial aspects of the granular cell layer of the upper blade of the dentate gyrus; (iii) antagonism of NMDA or glucocorticoid receptors, but not antagonism of mineralocorticoid receptors or inhibition of nitric oxide synthesis, attenuated the stress\u2010induced response; (iv) combined blockade of NMDA and glucocorticoid receptors ablated the stress\u2010induced histone modification response; (v) moreover, this combined blockade also abolished the induction of the P(Ser10)\u2010Ac(Lys14)\u2010H3\u2010associated gene product c\u2010fos after stress; (vi) administration of corticosterone to unstressed rats did not affect histone H3 phospho\u2010acetylation. Thus, novelty stress induces chromatin remodelling and c\u2010fos induction in mature dentate neurons through concurrent signalling via the NMDA receptor and the glucocorticoid receptor.<\/jats:p>","DOI":"10.1111\/j.1471-4159.2006.04396.x","type":"journal-article","created":{"date-parts":[[2007,1,22]],"date-time":"2007-01-22T19:09:01Z","timestamp":1169492941000},"page":"815-828","source":"Crossref","is-referenced-by-count":108,"title":["Novelty stress induces phospho\u2010acetylation of histone H3 in rat dentate gyrus granule neurons through coincident signalling via the <i>N<\/i>\u2010methyl\u2010<scp>d<\/scp>\u2010aspartate receptor and the glucocorticoid receptor: relevance for c\u2010fos induction"],"prefix":"10.1111","volume":"101","author":[{"given":"Yalini","family":"Chandramohan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne K.","family":"Droste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes M. 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