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In a screening approach for different ion channels in neural progenitor cells (NPCs) we observed a 1\u2010ethyl\u20102\u2010benzimidazolinone (1\u2010EBIO) activated inward current, which could be blocked by scyllatoxin (ScTX, IC<jats:sub>50<\/jats:sub>\u2003=\u20032\u2003\u00b1\u20030.3\u2003nmol\/L). This initial evidence for the expression of the small conductance Ca<jats:sup>2+<\/jats:sup> activated K<jats:sup>+<\/jats:sup>\u2010channel SK3 was confirmed by the detection of SK3 transcripts and protein in NPCs. Interestingly, SK3 proteins were highly expressed in non\u2010differentiated NPCs with a focused localization in lamellipodia as well as filopodial structures. The activation of SK3 channels using 1\u2010EBIO lead to an immediate filopodial sprouting and the translocation of the protein into these novel filopodial protrusions. Both effects could be prevented by the pre\u2010incubation of NPCs with ScTX. Our study gives first evidence that the formation and prolongation of filopodia in NPCs is, at least in part, effectively induced and regulated by SK3 channels.<\/jats:p>","DOI":"10.1111\/j.1471-4159.2006.04437.x","type":"journal-article","created":{"date-parts":[[2007,2,13]],"date-time":"2007-02-13T19:30:50Z","timestamp":1171395050000},"page":"1338-1350","source":"Crossref","is-referenced-by-count":41,"title":["Formation of cellular projections in neural progenitor cells depends on SK3 channel activity"],"prefix":"10.1111","volume":"101","author":[{"given":"Stefan","family":"Liebau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Vaida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Proepper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Grissmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Storch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias M.","family":"Boeckers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Dietl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver H.","family":"Wittekindt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,1,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2002.01204.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0602443103"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"6499","DOI":"10.1523\/JNEUROSCI.22-15-06499.2002","article-title":"Localization of the activation gate for small conductance Ca2+\u2010activated K+ channels","volume":"22","author":"Bruening\u2010Wright A.","year":"2002","journal-title":"J. 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