{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:55:32Z","timestamp":1767707732203},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,4,27]],"date-time":"2007-04-27T00:00:00Z","timestamp":1177632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Aneurysmal subarachnoid hemorrhage is a stroke subtype with high rates of mortality and morbidity. Cerebral vasospasm can lead to ischemic injury or death and is a common complication of aneurysmal subarachnoid hemorrhage, usually occurring 3\u20139\u2003days afterwards. The cause of vasospasm is not known. Recently, there has been strong evidence that vasoactive oxidation products of bilirubin may be involved. Currently, the factors that lead to bilirubin oxidation are poorly characterized. In this study, we have designed an <jats:italic>in vitro<\/jats:italic> model of hemorrhagic stroke in order to investigate conditions that promote the oxidation of bilirubin to form vasoactive compounds. Using our model, we created a basic hematoma system of blood, CSF, and hemeoxygenase\u20101. We manipulated this system in various ways, incubated it and determined the concentration of vasoactive bilirubin oxidation products that resulted. Conditions where cytochrome oxidase was stimulated caused an increase bilirubin oxidation products (292.6\u2003\u00b1\u200339.9\u2003\u03bcmol\/L respectively, vs. 79.3\u2003\u00b1\u20031.3\u2003\u03bcmol\/L for the basic reaction, <jats:italic>p<\/jats:italic>\u2003&lt;\u20030.05), which was attenuated by cyanide. Our data suggest that bilirubin oxidation products may be produced by oxidation(s) requiring an oxygen\u2010utilizing enzyme like cytochrome oxidase.<\/jats:p>","DOI":"10.1111\/j.1471-4159.2007.04667.x","type":"journal-article","created":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T08:24:46Z","timestamp":1180686286000},"page":"1990-1995","source":"Crossref","is-referenced-by-count":14,"title":["An <i>in vitro<\/i> model of aneurysmal subarachnoid hemorrhage: oxidation of unconjugated bilirubin by cytochrome oxidase"],"prefix":"10.1111","volume":"102","author":[{"given":"Matthew C.","family":"Loftspring","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William L.","family":"Wurster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gail J.","family":"Pyne\u2010Geithman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph F.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1179\/016164106X115053"},{"key":"e_1_2_7_3_1","first-page":"199","article-title":"The generation of reactive oxygen\u2010derived species by phagocytes","volume":"30","author":"Bergstrand H.","year":"1990","journal-title":"Agents Actions Suppl."},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.27.3.198"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000097769.47306.12"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2005.06.025"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathophys.2005.02.007"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600280"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200204000-00011"},{"key":"e_1_2_7_10_1","first-page":"S22","article-title":"Mechanisms of activation of NADPH oxidases","volume":"57","author":"Clark R. 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