{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:49:39Z","timestamp":1791978579043,"version":"4.4.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:00:00Z","timestamp":1181347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The ancient conserved domain protein (ACDP) family are a recently identified group of homologous mammalian proteins. Some family members have been suggested to have roles in the metabolism of metals. We investigated the capacity of ACDP\u20101 to bind metals. Using immobilised metal affinity chromatography and isothermal titration calorimetry we determined that ACDP\u20101 is a high affinity copper binding protein able to bind copper at nanomolar concentrations. In addition the promoter of ACDP\u20101 contains metal response elements and the cellular expression of ACDP\u20101 alters cellular retention of copper. However, cellular expression of ACDP\u20101 does not alter cellular resistance to the toxicity of copper or other metals. As our findings place the subcellular localisation of ACDP\u20101 in the cytoplasm it is possible that ACDP\u20101 represent a novel copper chaperone or storage protein.<\/jats:p>","DOI":"10.1111\/j.1471-4159.2007.04751.x","type":"journal-article","created":{"date-parts":[[2007,7,2]],"date-time":"2007-07-02T15:09:38Z","timestamp":1183388978000},"page":"312-321","source":"Crossref","is-referenced-by-count":13,"title":["Ancient conserved domain protein\u20101 binds copper and modifies its retention in cells"],"prefix":"10.1111","volume":"103","author":[{"given":"Alexandra","family":"Alderton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Illman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,6,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00480.2002"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.13.3351"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1033.2003.03717.x"},{"key":"e_1_2_6_5_1","volume-title":"Data for Biochemical Research","author":"Dawson R. 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