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The SPCA1 isoform shows a wide distribution in the neurons of pig cerebellum, where it is found in the Golgi complex of the soma of Purkinje, stellate, basket and granule cells, and also in more distal components of the secretory pathway associated with a synaptic localization such as in cerebellar glomeruli. The SPCA1 may be involved in loading the Golgi complex and the secretory vesicles of these specific neuronal cell types with Ca<jats:sup>2+<\/jats:sup> and also Mn<jats:sup>2+<\/jats:sup>. This study of the cellular and subcellular localization of SPCA1 pumps relative to the sarco(endo) plasmic reticulum Ca<jats:sup>2+<\/jats:sup>\u2010ATPase and plasma membrane Ca<jats:sup>2+<\/jats:sup>\u2010ATPase pumps hints to a possible specific role of SPCA1 in controlling the luminal secretory pathway Ca<jats:sup>2+<\/jats:sup> (or Mn<jats:sup>2+<\/jats:sup>) levels as well as the local cytosolic Ca<jats:sup>2+<\/jats:sup> levels. In addition, it helps to specify the zones that are most vulnerable to Ca<jats:sup>2+<\/jats:sup> and\/or Mn<jats:sup>2+<\/jats:sup> dyshomeostasis, a condition that is held responsible of an increasing number of neurological disorders.<\/jats:p>","DOI":"10.1111\/j.1471-4159.2007.04794.x","type":"journal-article","created":{"date-parts":[[2007,8,7]],"date-time":"2007-08-07T05:30:20Z","timestamp":1186464620000},"page":"1009-1018","source":"Crossref","is-referenced-by-count":30,"title":["Functional and immunocytochemical evidence for the expression and localization of the secretory pathway Ca<sup>2+<\/sup>\u2010ATPase isoform 1 (SPCA1) in cerebellum relative to other Ca<sup>2+<\/sup> pumps"],"prefix":"10.1111","volume":"103","author":[{"given":"M. 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