{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:17:15Z","timestamp":1787793435893,"version":"build-2784847793"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,7,3]],"date-time":"2007-07-03T00:00:00Z","timestamp":1183420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Seizures are a major complication of viral encephalitis. However, the mechanisms of seizure\u2010associated neuronal dysfunction remain poorly understood. We report that intranasal inoculation with West Nile virus (WNV) (Sarafend) causes limbic seizures in C57BL\/6 mice, but not in interferon (IFN)\u2010\u03b3\u2010deficient (IFN\u2010\u03b3<jats:sup>\u2212\/\u2212<\/jats:sup>) mice. Both strains showed similar levels of virus in the brain, as well as similar concentrations of the cytokines, tumor necrosis factor and interleukin\u20106, both of which can alter neuronal excitability. Experiments in chimeric IFN\u2010\u03b3<jats:sup>\u2212\/\u2212<\/jats:sup>mice reconstituted with IFN\u2010\u03b3\u2010producing leukocytes showed that IFN\u2010\u03b3 is not required during central nervous system infection for limbic seizure development, suggesting a role for IFN\u2010\u03b3 in the developing brain. This was supported responses to pentylenetetrazole, kainic acid (KA), and<jats:italic>N<\/jats:italic>\u2010methyl\u2010<jats:sc>d<\/jats:sc>\u2010aspartate (NMDA). Both strains of mice exhibited similar behavior after pentylenetetrazole challenge. However, while NMDA and KA treatment resulted in characteristic seizures in C57BL\/6 mice, these responses were diminished (NMDA treatment) or absent (KA treatment) in IFN\u2010\u03b3<jats:sup>\u2212\/\u2212<\/jats:sup>mice. Furthermore, NMDA\u2010receptor blockade with MK\u2010801 in WNV\u2010infected C57BL\/6 mice abrogated seizures and prolonged survival. Our data show that IFN\u2010\u03b3 plays an important role in the development of the excitatory seizure pathways in the brain and that these cascades become pathogenic in encephalitic WNV infection.<\/jats:p>","DOI":"10.1111\/j.1471-4159.2007.04798.x","type":"journal-article","created":{"date-parts":[[2007,9,13]],"date-time":"2007-09-13T12:51:50Z","timestamp":1189687910000},"page":"1019-1030","source":"Crossref","is-referenced-by-count":67,"title":["Role of IFN\u2010\u03b3 in an experimental murine model of West Nile virus\u2010induced seizures"],"prefix":"10.1111","volume":"103","author":[{"given":"Daniel R.","family":"Getts","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izuru","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghann Teague","family":"Getts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Radford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bimmi","family":"Shrestha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain L.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J. C.","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,7,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1684\/epd.2007.0056","article-title":"Electro\u2010clinical evolution of refractory non\u2010convulsive status epilepticus caused by West Nile virus encephalitis","volume":"9","author":"Bagic A.","year":"2007","journal-title":"Epileptic Disord."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1204.051379"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2006.03.013"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(03)00023-6"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.56.012302.160654"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.21.10061"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"716","DOI":"10.4049\/jimmunol.152.2.716","article-title":"Cerebral expression of multiple cytokine genes in mice with lymphocytic choriomeningitis","volume":"152","author":"Campbell I. L.","year":"1994","journal-title":"J. Immunol."},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(02)00368-7"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0013-9580.2004.37403.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2003.09.015"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20031223"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/08830738060210051101"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0387-7604(02)00162-6"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1600-0404.2003.00238.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.01775.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1086\/379516"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5245(02)00061-5"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-1211(02)00018-9"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0505.990506"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/13550280600758341"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.icb.7100012"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(02)00135-1"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M311766200"},{"key":"e_1_2_7_25_1","first-page":"53","article-title":"Two models of ethanol withdrawal kindling","volume":"36","author":"Matsumoto I.","year":"2001","journal-title":"Nihon Arukoru Yakubutsu Igakkai Zasshi"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(03)00562-1"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5321-06.2007"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.15.7114-7121.2001"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20033"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.186.12.2023"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2004.10.069"},{"key":"e_1_2_7_32_1","first-page":"524","article-title":"Encephalitis due to West Nile fever virus","volume":"3","author":"Pruzanski W.","year":"1962","journal-title":"World Neurol."},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2005.12.010"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10635"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.15.8312-8321.2004"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.24.13203-13213.2003"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.326.7394.865"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/13550280390201704"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)00706-4"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01167-06"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.24.13323-13334.2003"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2004.08.004"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2006.10.007"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2003.03075.x"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2004.05.010"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-004-1944-1"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.11.014"}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1471-4159.2007.04798.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1471-4159.2007.04798.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T23:53:10Z","timestamp":1737417190000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1471-4159.2007.04798.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7,3]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,11]]}},"alternative-id":["10.1111\/j.1471-4159.2007.04798.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1471-4159.2007.04798.x","archive":["Portico"],"relation":{},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,7,3]]}}}