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In this study, we sought to reveal which cell death pathways are activated within these progenitors after H\/I. We found that calpain activity is detected as early as 4\u2003h of reperfusion and is sustained for 48\u2003h, while caspase 3 activation does not occur until 8\u2003h and peaks at 24\u2003h post\u2010insult. Activated calpains and caspase 3 co\u2010localized within precursors situated in the lateral aspects of the SVZ (which coincides with progenitor cell death), whereas neither enzyme was activated in the medial SVZ (which harbors the neural stem cells that are resilient to this insult). These studies reveal targets for neuroprotective agents to protect precursors from cell death towards the goal of restoring normal brain development after H\/I.<\/jats:p>","DOI":"10.1111\/j.1471-4159.2007.04820.x","type":"journal-article","created":{"date-parts":[[2007,8,18]],"date-time":"2007-08-18T08:12:56Z","timestamp":1187424776000},"page":"1121-1131","source":"Crossref","is-referenced-by-count":21,"title":["Death effector activation in the subventricular zone subsequent to perinatal hypoxia\/ischemia"],"prefix":"10.1111","volume":"103","author":[{"given":"Michael J.","family":"Romanko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changlian","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben A.","family":"Bahr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klas","family":"Blomgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven W.","family":"Levison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,7,11]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"902","article-title":"Induction of calpain\u2010mediated spectrin fragments by pathogenic treatments in long\u2010term hippocampal slices","volume":"273","author":"Bahr B. 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