{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T09:26:59Z","timestamp":1777541219175,"version":"3.51.4"},"reference-count":61,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,8,3]],"date-time":"2007-08-03T00:00:00Z","timestamp":1186099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effect of stress mediators following the stress period and addition time is a controversial issue until now. Thus, we aim to clarify the differential effects of single restraint stress (SS) or repeated restraint stress (RS) on kainic acid (KA)\u2010induced neuronal death especially as addressing not only the role of glucocorticoid (Gc) and its receptor but also the signal pathway leading to cAMP response element binding protein phosphorylation (pCREB) and its functional role during stress. In the present study, we found that although RS did not show any difference on serum Gc level and hippocampal Gc receptor level compared to SS, SS exacerbated KA\u2010induced neuronal death in hippocampal CA3 region, but RS did not. Moreover, pre\u2010treatment with RU 38486 (Gc receptor antagonist) abolished the effect of SS on KA\u2010induced neuronal death without an effect on KA toxicity itself. Furthermore, RS aggravates KA\u2010induced neuronal death when CREB phosphorylation was deprived by KN\u201093 (calcium\/calmodulin\u2010dependent protein kinase II inhibitor). However, other signal molecules inhibitors such as PD98059 (MEK1\/2 inhibitor) and SP600125 (p\u2010p38 inhibitor) have no effect on KA\u2010induced neuronal death after RS although these signal molecule were increased during SS or RS. These findings suggest that pCREB expression via calcium\/calmodulin\u2010dependent protein kinase II phosphorylation during RS comprise one of the balancers against Gc induced by stress.<\/jats:p>","DOI":"10.1111\/j.1471-4159.2007.04865.x","type":"journal-article","created":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T04:18:42Z","timestamp":1188620322000},"page":"1530-1541","source":"Crossref","is-referenced-by-count":20,"title":["The differential effects of single or repeated restraint stress on kainic acid\u2010induced neuronal death in the hippocampal CA3 region: the role of glucocorticoid and various signal molecules"],"prefix":"10.1111","volume":"103","author":[{"given":"Min\u2010Soo","family":"Kwon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young\u2010Jun","family":"Seo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung\u2010Min","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee\u2010Woo","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun\u2010Sub","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo\u2010Hyun","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong\u2010Won","family":"Suh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,8,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.96.09010160"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(96)00435-6"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.6.15.1464368"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.251194298"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5443.1358"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-12-04563.2000"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.15.4426"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)90371-9"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.201215298"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.01604.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00150.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1992.tb08345.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0039-128X(76)90028-3"},{"key":"e_1_2_7_15_1","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1161\/01.STR.32.6.1263","article-title":"Stress\u2010induced blood pressure reactivity and incident stroke in middle\u2010aged men","volume":"32","author":"Everson S. 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