{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:38:00Z","timestamp":1787060280764,"version":"build-2736575974"},"reference-count":74,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,8,9]],"date-time":"2007-08-09T00:00:00Z","timestamp":1186617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The\n                    <jats:italic>N<\/jats:italic>\n                    \u2010acylethanolamines (NAEs) and 2\u2010arachidonoylglycerol (2\u2010AG) are bioactive lipids that can modulate inflammatory responses and protect neurons against glutamatergic excitotoxicity. We have used a model of focal cerebral ischemia in young adult mice to investigate the relationship between focal cerebral ischemia and endogenous NAEs. Over the first 24\u2003h after induction of permanent middle cerebral artery occlusion, we observed a time\u2010dependent increase in all the investigated NAEs, except for anandamide. Moreover, we found an accumulation of 2\u2010AG at 4\u2003h that returned to basal level 12\u2003h after induction of ischemia. Accumulation of NAEs did not depend on regulation of\n                    <jats:italic>N<\/jats:italic>\n                    \u2010acylphosphatidylethanolamine\u2010hydrolyzing phospholipase D or fatty acid amide hydrolase. Treatment with the fatty acid amide hydrolase inhibitor URB597 (cyclohexyl carbamic acid 3\u2032\u2010carbamoyl\u2010biphenyl\u20103\u2010yl ester; 1\u2003mg\/kg; i.p.) 1.5\u2003h before arterial occlusion decreased the infarct volume in our model system. Our results suggest that NAEs and 2\u2010AG may be involved in regulation of neuroprotection during focal cerebral ischemia in mice.\n                  <\/jats:p>","DOI":"10.1111\/j.1471-4159.2007.04892.x","type":"journal-article","created":{"date-parts":[[2007,9,17]],"date-time":"2007-09-17T01:41:34Z","timestamp":1189993294000},"page":"1907-1916","source":"Crossref","is-referenced-by-count":73,"title":["Changes in brain levels of\n                    <i>N<\/i>\n                    \u2010acylethanolamines and 2\u2010arachidonoylglycerol in focal cerebral ischemia in mice"],"prefix":"10.1111","volume":"103","author":[{"given":"Matilda","family":"Degn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate 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