{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:01:11Z","timestamp":1761512471638},"reference-count":148,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,10,18]],"date-time":"2007-10-18T00:00:00Z","timestamp":1192665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:sec><jats:label \/><jats:p> <jats:italic>J. Neurochem.<\/jats:italic> (2008) <jats:bold>104,<\/jats:bold> 1450\u20131465.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Cholecystokinin (CCK) is abundantly expressed in the CNS, in which it regulates feeding behavior and long\u2010term memory. Moreover, CCK has been implicated in mental disorders, such as anxiety and schizophrenia. Despite its manifest physiological and pathophysiological role, the molecular targets of neuronal CCK are incompletely understood. To identify genes regulated by neuronal CCK, we generated neuronal PC12 cells stably expressing the CCK\u20102 receptor (CCK\u20102R) and treated the cells with sulphated CCK\u20108 for 2\u201316\u2003h, before the global expression profile was examined. The changes in gene expression peaked after 2\u2003h, with 67 differentially expressed transcripts identified. A pathway analysis indicated that CCK was implicated in the regulation of the circadian clock system, the plasminogen system and cholesterol metabolism. But transcripts encoding proteins involved in dopamine signaling, ornithine decarboxylase (ODC) regulation, memory and epidermal growth factor receptor (EGFR) signaling were also found. Several target genes contained cAMP response elements (CREs), serum response elements (SREs), activator protein 1 (AP1) elements and GC\u2010rich regions, but otherwise no common regulatory promoter element could be identified. Comparison with forskolin\u2010 and nerve growth factor (NGF)\u2010treated PC12 cells showed that CCK induced a separate set of target genes. Taken together, we propose that neuronal CCK may have a role in the regulation of the circadian rhythm, the metabolism of cerebral cholesterol and in the regulation of the plasminogen system.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1471-4159.2007.05076.x","type":"journal-article","created":{"date-parts":[[2007,11,20]],"date-time":"2007-11-20T04:50:33Z","timestamp":1195534233000},"page":"1450-1465","source":"Crossref","is-referenced-by-count":7,"title":["Cholecystokinin\u20102 receptor mediated gene expression in neuronal PC12 cells"],"prefix":"10.1111","volume":"104","author":[{"given":"Thomas v. 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