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(2008) <jats:bold>104,<\/jats:bold> 1674\u20131685.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Rats treated with (\u00b1)\u20103,4\u2010methylenedioxymethamphetamine (MDMA) or (+)\u2010methamphetamine (MA) neonatally exhibit long\u2010lasting learning impairments (i.e., after treatment on postnatal days (P)11\u201315 or P11\u201320). Although both drugs are substituted amphetamines, they each produce a unique profile of cognitive deficits (i.e., spatial vs. path integration learning and severity of deficits) which may be the result of differential early neurochemical changes. We previously showed that MA and MDMA increase corticosterone (CORT) and MDMA reduces levels of serotonin (5\u2010HT) 24\u2003h after treatment on P11, however, learning deficits are seen after 5 or 10\u2003days of drug treatment, not just 1\u2003day. Accordingly, in the present experiment, rats were treated with MA or MDMA starting on P11 for 5 or 10\u2003days (P11\u201315 or P11\u201320) and tissues collected on P16, P21, or P30. Five\u2010day MA administration dramatically increased CORT on P16, whereas MDMA did not. Both drugs decreased hippocampal 5\u2010HT on P16 and P21, although MDMA produced larger reductions. Ten\u2010day treatment with either drug increased dopamine utilization in the neostriatum on P21, whereas 5\u2010day treatment had no effect. No CORT or brain 5\u2010HT or dopamine changes were found with either drug on P30. Although the monoamine changes are transient, they may alter developing neural circuits sufficiently to permanently disrupt later learning and memory abilities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1471-4159.2007.05112.x","type":"journal-article","created":{"date-parts":[[2008,2,25]],"date-time":"2008-02-25T20:47:23Z","timestamp":1203972443000},"page":"1674-1685","source":"Crossref","is-referenced-by-count":42,"title":["Short\u2010 and long\u2010term effects of (+)\u2010methamphetamine and (\u00b1)\u20103,4\u2010methylenedioxymethamphetamine on monoamine and corticosterone levels in the neonatal rat following multiple days of treatment"],"prefix":"10.1111","volume":"104","author":[{"given":"Tori L.","family":"Schaefer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Skelton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole R.","family":"Herring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary A.","family":"Gudelsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles V.","family":"Vorhees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,11,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301091"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2006.12.013"},{"key":"e_1_2_8_4_1","first-page":"83","article-title":"Timetables of Neurogenesis in the Human Brain Based on Experimentally Determined Patterns in the Rat","volume":"14","author":"Bayer S. 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