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We have shown that the flavonoid kaempferol largely reduced striatal damage induced by cerebral ischaemia\u2010reperfusion in rats (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#b50\">Lopez\u2010Sanchez <jats:italic>et\u00a0al.<\/jats:italic> 2007<\/jats:ext-link>). In this work, we report that intraperitoneal (i.p.) administration of kaempferol affords an efficient protection against NPA\u2010induced neurodegeneration in Wistar rats. We studied the effects of daily i.p. injections of 7, 14 and 21\u2003mg of kaempferol\/kg body weight during the NPA\u2010treatment (25\u2003mg\/kg body weight\/12\u2003h i.p., for 5\u2003days) on the neurological deficits, degeneration of rat striatum and oxidative stress markers. Intraperitoneal injections of 14\u201321\u2003mg of kaempferol\/kg body weight largely attenuated motor deficit and delayed mortality. The higher dose of kaempferol prevented the appearance of NPA\u2010induced striatal lesions up to the end of treatment, as revealed by haematoxylin\u2010eosin and TUNEL staining, and also NPA\u2010induced oxidative stress, because it blocked the fall of reduced glutathione and the increase of protein nitrotyrosines in NPA\u2010treated rats. It was found that striatal degeneration was associated with calpains activation and a large inactivation of creatine kinase, which were also prevented when the higher doses of kaempferol were administered.<\/jats:p>","DOI":"10.1111\/j.1471-4159.2009.06331.x","type":"journal-article","created":{"date-parts":[[2009,8,13]],"date-time":"2009-08-13T08:59:14Z","timestamp":1250153954000},"page":"473-487","source":"Crossref","is-referenced-by-count":78,"title":["Kaempferol protects against rat striatal degeneration induced by 3\u2010nitropropionic acid"],"prefix":"10.1111","volume":"111","author":[{"given":"Ricardo","family":"Lagoa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Lopez\u2010Sanchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro 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