{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:29:01Z","timestamp":1790947741840,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,1,28]],"date-time":"2011-01-28T00:00:00Z","timestamp":1296172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:sec><jats:label\/><jats:p> <jats:italic>J. Neurochem.<\/jats:italic> (2011) <jats:bold>116<\/jats:bold>, 1148\u20131159.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>This study was designed to test the hypothesis that improved mitochondrial biogenesis could help reducing ischemic cerebral injury. We found that levels of proliferator\u2010activated receptor \u03b3 coactivator 1\u03b1 and nuclear respiratory factor\u20101, mitochondrial DNA content and other markers of mitochondrial biogenesis and function were reduced in primary mouse cortical neurons under oxygen\u2010glucose deprivation (OGD). The glycogen synthase kinase\u20103 (GSK\u20103) inhibitor SB216763 activated an efficient mitochondrial biogenesis program in control cortical neurons and counteracted the OGD\u2010mediated mitochondrial biogenesis impairment. This was accompanied by the activation of an antioxidant response that reduced mitochondrial reactive oxygen species generation and ischemic neuronal damage. The <jats:italic>in vitro<\/jats:italic> effects of SB216763 were mimicked by two other structurally unrelated GSK\u20103 inhibitors. The protective effects of SB216763 on OGD\u2010mediated neuronal damage were abolished in the presence of diverse mitochondrial inhibitors. Finally, when systemically administered <jats:italic>in vivo<\/jats:italic>, SB216763 reduced the infarct size and recovered the loss of mitochondrial DNA in mice subjected to permanent middle cerebral artery occlusion. We conclude that GSK\u20103 inhibition by SB216763 might pave the way of novel promising therapies aimed at stimulating the renewal of functional mitochondria and reducing reactive oxygen species\u2010mediated damage in ischemic stroke.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1471-4159.2011.07171.x","type":"journal-article","created":{"date-parts":[[2011,1,6]],"date-time":"2011-01-06T23:15:59Z","timestamp":1294355759000},"page":"1148-1159","source":"Crossref","is-referenced-by-count":112,"title":["Glycogen synthase kinase\u20103 inhibition reduces ischemic cerebral damage, restores impaired mitochondrial biogenesis and prevents ROS production"],"prefix":"10.1111","volume":"116","author":[{"given":"Alessandra","family":"Valerio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Bertolotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Delbarba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Perego","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Dossena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Ragni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PierFranco","family":"Spano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele O.","family":"Carruba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Grazia","family":"De Simoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enzo","family":"Nisoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,1,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2009.04.005"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600595"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600251"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M306268200"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408440802014287"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/hs1001.097099"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-5521(00)00025-9"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.05.051"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2010.08.016"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1178-08.2008"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3758\/BF03193146"},{"key":"e_1_2_7_13_1","volume-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Franklin K. B. J.","year":"1997"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2665"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M702793200"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/db06-0907"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.01.007"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5654-07.2008"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.197996"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2005.09.009"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(02)02071-0"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.05.006"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.091637"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M607468200"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2008.06.014"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.12.044"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2005.05.001"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2003.11.010"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2004.07.006"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21567"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1079368"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1624208"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199802000-00011"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.00661.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000338597.71702.ad"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2008.08.003"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-010-0024-6"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00025.2007"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.9.7.1071"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707471"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21498"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.106.105064"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.09.024"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-1623"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000012567.95445.55"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M508691200"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.528588"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.543769"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-0899"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.520114"}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1471-4159.2011.07171.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1471-4159.2011.07171.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T20:56:53Z","timestamp":1697317013000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1471-4159.2011.07171.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,28]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["10.1111\/j.1471-4159.2011.07171.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1471-4159.2011.07171.x","archive":["Portico"],"relation":{},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,28]]}}}