{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:14:46Z","timestamp":1791252886091,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1589,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1111\/j.1471-4159.2011.07257.x","type":"journal-article","created":{"date-parts":[[2011,3,28]],"date-time":"2011-03-28T15:06:30Z","timestamp":1301324790000},"page":"892-903","source":"Crossref","is-referenced-by-count":61,"title":["Hepatocyte growth factor protects retinal ganglion cells by increasing neuronal survival and axonal regeneration in vitro and in vivo"],"prefix":"10.1111","volume":"117","author":[{"given":"Lars","family":"T\u00f6nges","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Ostendorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne","family":"Lamballe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Genestine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosanna","family":"Dono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-Christoph","family":"Koch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"B\u00e4hr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio","family":"Maina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Lingor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,4,26]]},"reference":[{"key":"10.1111\/j.1471-4159.2011.07257.x-BIB1|cit1","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S0166-2236(00)01637-4","article-title":"Live or let die - retinal ganglion cell death and survival during development and in the lesioned adult CNS","volume":"23","author":"Bahr","year":"2000","journal-title":"Trends Neurosci."},{"key":"10.1111\/j.1471-4159.2011.07257.x-BIB2|cit2","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/0896-6273(88)90127-4","article-title":"Immunological, morphological, and electrophysiological variation among retinal ganglion cells purified by panning","volume":"1","author":"Barres","year":"1988","journal-title":"Neuron"},{"key":"10.1111\/j.1471-4159.2011.07257.x-BIB3|cit3","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/S0962-8924(98)01359-2","article-title":"Developmental roles of HGF\/SF and its receptor, the c-Met tyrosine kinase","volume":"8","author":"Birchmeier","year":"1998","journal-title":"Trends Cell Biol."},{"key":"10.1111\/j.1471-4159.2011.07257.x-BIB4|cit4","doi-asserted-by":"crossref","first-page":"10608","DOI":"10.1073\/pnas.0403412101","article-title":"Met provides essential signals for liver regeneration","volume":"101","author":"Borowiak","year":"2004","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1111\/j.1471-4159.2011.07257.x-BIB5|cit5","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1126\/science.1846706","article-title":"Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product","volume":"251","author":"Bottaro","year":"1991","journal-title":"Science"},{"key":"10.1111\/j.1471-4159.2011.07257.x-BIB6|cit6","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/S0166-2236(02)02255-5","article-title":"Axon pathology in neurological disease: a neglected therapeutic target","volume":"25","author":"Coleman","year":"2002","journal-title":"Trends Neurosci."},{"key":"10.1111\/j.1471-4159.2011.07257.x-BIB7|cit7","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/S0896-6273(00)80247-0","article-title":"Hepatocyte growth factor\/scatter factor is an axonal chemoattractant and a neurotrophic factor for spinal motor neurons","volume":"17","author":"Ebens","year":"1996","journal-title":"Neuron"},{"key":"10.1111\/j.1471-4159.2011.07257.x-BIB8|cit8","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/nrn1195","article-title":"Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS","volume":"4","author":"Filbin","year":"2003","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1111\/j.1471-4159.2011.07257.x-BIB9|cit9","doi-asserted-by":"crossref","first-page":"8726","DOI":"10.1523\/JNEUROSCI.2774-04.2004","article-title":"Switching mature retinal ganglion cells to a robust growth state in vivo: gene expression and synergy with RhoA inactivation","volume":"24","author":"Fischer","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1111\/j.1471-4159.2011.07257.x-BIB10|cit10","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1523\/JNEUROSCI.4979-06.2007","article-title":"Hepatocyte growth factor acts as a motogen and guidance signal for gonadotropin hormone-releasing hormone-1 neuronal migration","volume":"27","author":"Giacobini","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1111\/j.1471-4159.2011.07257.x-BIB11|cit11","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1002\/(SICI)1097-4547(19960301)43:5<554::AID-JNR5>3.0.CO;2-H","article-title":"Neurotrophic effect of hepatocyte growth factor on central nervous system neurons in vitro","volume":"43","author":"Hamanoue","year":"1996","journal-title":"J. Neurosci. Res."},{"key":"10.1111\/j.1471-4159.2011.07257.x-BIB12|cit12","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S0896-6273(03)00493-8","article-title":"Met signaling is required for recruitment of motor neurons to PEA3-positive motor pools","volume":"39","author":"Helmbacher","year":"2003","journal-title":"Neuron"},{"key":"10.1111\/j.1471-4159.2011.07257.x-BIB13|cit13","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1046\/j.1471-4159.2002.00837.x","article-title":"Neuroprotection by scatter factor\/hepatocyte growth factor and FGF-1 in cerebellar granule neurons is phosphatidylinositol 3-kinase\/akt-dependent and MAPK\/CREB-independent","volume":"81","author":"Hossain","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1111\/j.1471-4159.2011.07257.x-BIB14|cit14","doi-asserted-by":"crossref","first-page":"4477","DOI":"10.1073\/pnas.0306068101","article-title":"Hepatocyte growth factor\/c-met signaling pathway is required for efficient liver regeneration and repair","volume":"101","author":"Huh","year":"2004","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1111\/j.1471-4159.2011.07257.x-BIB15|cit15","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.neures.2007.08.017","article-title":"Hepatocyte growth factor (HGF) attenuates gliosis and motoneuronal degeneration in the brainstem motor nuclei of a transgenic mouse model of ALS","volume":"59","author":"Kadoyama","year":"2007","journal-title":"Neurosci. Res."},{"key":"10.1111\/j.1471-4159.2011.07257.x-BIB16|cit16","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.neures.2009.06.016","article-title":"Disease-dependent reciprocal phosphorylation of serine and tyrosine residues of c-Met\/HGF receptor contributes disease retardation of a transgenic mouse model of ALS","volume":"65","author":"Kadoyama","year":"2009","journal-title":"Neurosci. Res."},{"key":"10.1111\/j.1471-4159.2011.07257.x-BIB17|cit17","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.neures.2005.04.004","article-title":"Nonviral HVJ (hemagglutinating virus of Japan) liposome-mediated retrograde gene transfer of human hepatocyte growth factor into rat nervous system promotes functional and histological recovery of the crushed nerve","volume":"52","author":"Kato","year":"2005","journal-title":"Neurosci. Res."},{"key":"10.1111\/j.1471-4159.2011.07257.x-BIB18|cit18","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1002\/jnr.21372","article-title":"Hepatocyte growth factor promotes endogenous repair and functional recovery after spinal cord injury","volume":"85","author":"Kitamura","year":"2007","journal-title":"J. Neurosci. Res."},{"key":"10.1111\/j.1471-4159.2011.07257.x-BIB19|cit19","doi-asserted-by":"crossref","first-page":"6064","DOI":"10.1073\/pnas.0909794107","article-title":"Mechanisms of acute axonal degeneration in the optic nerve in vivo","volume":"107","author":"Kn\u00f6ferle","year":"2010","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1111\/j.1471-4159.2011.07257.x-BIB20|cit20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0169-328X(00)00224-2","article-title":"Characterization of a transformed rat retinal ganglion cell line","volume":"86","author":"Krishnamoorthy","year":"2001","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1111\/j.1471-4159.2011.07257.x-BIB21|cit21","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.cellsig.2007.12.013","article-title":"Hepatocyte growth factor and c-Met promote dendritic maturation during hippocampal neuron differentiation via the Akt pathway","volume":"20","author":"Lim","year":"2008","journal-title":"Cell. Signal."},{"key":"10.1111\/j.1471-4159.2011.07257.x-BIB22|cit22","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1093\/brain\/awm284","article-title":"ROCK inhibition and CNTF interact on intrinsic signalling pathways and differentially regulate survival and regeneration in retinal ganglion cells","volume":"131","author":"Lingor","year":"2008","journal-title":"Brain"},{"key":"10.1111\/j.1471-4159.2011.07257.x-BIB23|cit23","doi-asserted-by":"crossref","first-page":"4174","DOI":"10.1167\/iovs.04-0455","article-title":"Neuroprotective effect of hepatocyte growth factor against photoreceptor degeneration in rats","volume":"45","author":"Machida","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1111\/j.1471-4159.2011.07257.x-BIB24|cit24","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/6310","article-title":"Hepatocyte growth factor, a versatile signal for developing neurons","volume":"2","author":"Maina","year":"1999","journal-title":"Nat. Neurosci."},{"key":"10.1111\/j.1471-4159.2011.07257.x-BIB25|cit25","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0092-8674(00)81372-0","article-title":"Uncoupling of Grb2 from the Met receptor in vivo reveals complex roles in muscle development","volume":"87","author":"Maina","year":"1996","journal-title":"Cell"},{"key":"10.1111\/j.1471-4159.2011.07257.x-BIB26|cit26","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.1101\/gad.11.24.3341","article-title":"Met receptor signaling is required for sensory nerve development and HGF promotes axonal growth and survival of sensory neurons","volume":"11","author":"Maina","year":"1997","journal-title":"Genes Dev."},{"key":"10.1111\/j.1471-4159.2011.07257.x-BIB27|cit27","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/S0896-6273(00)80466-3","article-title":"Multiple roles for hepatocyte growth factor in sympathetic neuron development","volume":"20","author":"Maina","year":"1998","journal-title":"Neuron"},{"key":"10.1111\/j.1471-4159.2011.07257.x-BIB28|cit28","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/S1097-2765(01)00261-1","article-title":"Coupling Met to specific pathways results in distinct developmental outcomes","volume":"7","author":"Maina","year":"2001","journal-title":"Mol. Cell"},{"key":"10.1111\/j.1471-4159.2011.07257.x-BIB29|cit29","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/S0021-5155(03)00003-0","article-title":"Hepatocyte growth factor stimulates proliferation and migration during wound healing of retinal pigment epithelial cells in vitro","volume":"47","author":"Miura","year":"2003","journal-title":"Jpn. J. Ophthalmol."},{"key":"10.1111\/j.1471-4159.2011.07257.x-BIB30|cit30","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1093\/brain\/awn196","article-title":"BAG1 promotes axonal outgrowth and regeneration in vivo via Raf-1 and reduction of ROCK activity","volume":"131","author":"Planchamp","year":"2008","journal-title":"Brain"},{"key":"10.1111\/j.1471-4159.2011.07257.x-BIB31|cit31","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/0014-4827(92)90430-G","article-title":"Lectin-induced differentiation of transformed neuroretinal cells in vitro","volume":"199","author":"Seigel","year":"1992","journal-title":"Exp. Cell Res."},{"key":"10.1111\/j.1471-4159.2011.07257.x-BIB32|cit32","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.jtcvs.2006.06.018","article-title":"Nonviral gene transfer of hepatocyte growth factor attenuates neurologic injury after spinal cord ischemia in rabbits","volume":"132","author":"Shi","year":"2006","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"10.1111\/j.1471-4159.2011.07257.x-BIB33|cit33","first-page":"528","article-title":"Expression and neuroprotective effect of hepatocyte growth factor in retinal ischemia-reperfusion injury","volume":"43","author":"Shibuki","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1111\/j.1471-4159.2011.07257.x-BIB34|cit34","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/S0006-8993(99)02097-1","article-title":"Differential expression of hepatocyte growth factor and its receptor, c-Met in the rat retina during development","volume":"851","author":"Sun","year":"1999","journal-title":"Brain Res."},{"key":"10.1111\/j.1471-4159.2011.07257.x-BIB35|cit35","doi-asserted-by":"crossref","first-page":"6537","DOI":"10.1523\/JNEUROSCI.22-15-06537.2002","article-title":"Overexpression of HGF retards disease progression and prolongs life span in a transgenic mouse model of ALS","volume":"22","author":"Sun","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1111\/j.1471-4159.2011.07257.x-BIB36|cit36","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1111\/j.1471-4159.2004.02809.x","article-title":"The neuregulin receptor, ErbB4, is not required for normal development and adult maintenance of the substantia nigra pars compacta","volume":"91","author":"Thuret","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1111\/j.1471-4159.2011.07257.x-BIB37|cit37","doi-asserted-by":"crossref","first-page":"4267","DOI":"10.1167\/iovs.09-3484","article-title":"Recharacterization of the RGC-5 retinal ganglion cell line","volume":"50","author":"Van Bergen","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1111\/j.1471-4159.2011.07257.x-BIB38|cit38","doi-asserted-by":"crossref","first-page":"5187","DOI":"10.1074\/jbc.272.8.5187","article-title":"Hepatocyte growth factor promotes motor neuron survival and synergizes with ciliary neurotrophic factor","volume":"272","author":"Wong","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1111\/j.1471-4159.2011.07257.x-BIB39|cit39","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1073\/pnas.011532898","article-title":"Anti-apoptotic signaling by hepatocyte growth factor\/Met via the phosphatidylinositol 3-kinase\/Akt and mitogen-activated protein kinase pathways","volume":"98","author":"Xiao","year":"2001","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1111\/j.1471-4159.2011.07257.x-BIB40|cit40","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.1242\/dev.124.15.2903","article-title":"Hepatocyte growth factor (HGF\/SF) is a muscle-derived survival factor for a subpopulation of embryonic motoneurons","volume":"124","author":"Yamamoto","year":"1997","journal-title":"Development"},{"key":"10.1111\/j.1471-4159.2011.07257.x-BIB41|cit41","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1089\/scd.2006.15.943","article-title":"Oligodendrocyte progenitor cells derived from human embryonic stem cells express neurotrophic factors","volume":"15","author":"Zhang","year":"2006","journal-title":"Stem Cells Dev."}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1471-4159.2011.07257.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/j.1471-4159.2011.07257.x\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T20:21:05Z","timestamp":1637439665000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1471-4159.2011.07257.x"}},"subtitle":["HGF for RGC survival and regeneration"],"short-title":[],"issued":{"date-parts":[[2011,4,26]]},"references-count":41,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,6]]}},"URL":"https:\/\/doi.org\/10.1111\/j.1471-4159.2011.07257.x","relation":{},"ISSN":["0022-3042"],"issn-type":[{"value":"0022-3042","type":"print"}],"subject":[],"published":{"date-parts":[[2011,4,26]]}}}