{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T09:22:10Z","timestamp":1791105730050,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,5,25]],"date-time":"2011-05-25T00:00:00Z","timestamp":1306281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:sec><jats:label\/><jats:p><jats:italic>J. Neurochem.<\/jats:italic>(2011) 10.1111\/j.1471\u20104159.2011.07292.x<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p><jats:sc>l<\/jats:sc>\u2010DOPA is the most commonly used treatment for symptomatic control in patients with Parkinson\u2019s disease. Unfortunately, most patients develop severe side\u2010effects, such as dyskinesia, upon chronic<jats:sc>l<\/jats:sc>\u2010DOPA treatment. The patophysiology of dyskinesia is unclear; however, involvement of serotonergic nerve fibers in converting<jats:sc>l\u2010<\/jats:sc>DOPA to dopamine has been suggested. Therefore, potassium\u2010evoked dopamine release was studied after local application of<jats:sc>l\u2010<\/jats:sc>DOPA in the striata of normal, dopamine\u2010 and dopamine\/serotonin\u2010lesioned<jats:sc>l\u2010<\/jats:sc>DOPA na\u00efve, and dopamine\u2010denervated chronically<jats:sc>l\u2010<\/jats:sc>DOPA\u2010treated dyskinetic rats using<jats:italic>in vivo<\/jats:italic>chronoamperometry. The results revealed that local<jats:sc>l\u2010<\/jats:sc>DOPA administration into normal and intact hemisphere of dopamine\u2010lesioned<jats:sc>l\u2010<\/jats:sc>DOPA na\u00efve animals significantly increased the potassium\u2010evoked dopamine release.<jats:sc>l\u2010<\/jats:sc>DOPA application also increased the dopamine peak amplitude in the dopamine\u2010depleted<jats:sc>l\u2010<\/jats:sc>DOPA na\u00efve striatum, although these dopamine levels were several\u2010folds lower than in the normal striatum, whereas no increased dopamine release was found in the dopamine\/serotonin\u2010denervated striatum. In dyskinetic animals, local<jats:sc>l\u2010<\/jats:sc>DOPA application did not affect the dopamine release, resulting in significantly attenuated dopamine levels compared with those measured in<jats:sc>l\u2010<\/jats:sc>DOPA na\u00efve dopamine\u2010denervated striatum. To conclude,<jats:sc>l<\/jats:sc>\u2010DOPA is most likely converted to dopamine in serotonergic nerve fibers in the dopamine\u2010depleted striatum, but the dopamine release is several\u2010fold lower than in normal striatum. Furthermore,<jats:sc>l\u2010<\/jats:sc>DOPA loading does not increase the dopamine release in dyskinetic animals as found in<jats:sc>l\u2010<\/jats:sc>DOPA na\u00efve animals, despite similar density of serotonergic innervation. Thus, the dopamine overflow produced from the serotonergic nerve fibers appears not to be the major cause of dyskinetic behavior.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1471-4159.2011.07292.x","type":"journal-article","created":{"date-parts":[[2011,4,29]],"date-time":"2011-04-29T15:01:53Z","timestamp":1304089313000},"page":"12-23","source":"Crossref","is-referenced-by-count":45,"title":["Dopamine release from serotonergic nerve fibers is reduced in<scp>L<\/scp>\u2010DOPA\u2010induced dyskinesia"],"prefix":"10.1111","volume":"118","author":[{"given":"Nina","family":"Nevalainen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"af Bjerk\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Lundblad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg A.","family":"Gerhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Str\u00f6mberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,5,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.1090"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(95)11817-G"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2005.10.022"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20370"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2007.08.010"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2079-07.2007"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn305"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.03696.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm082"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471142301.ns0925s41"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1998.00285.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2008.06040.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.05.005"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.20630"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(84)90963-6"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1978.tb14835.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2008.11.001"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.04196.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0022-3565(25)32511-5","article-title":"The site of dopamine formation in rat striatum after L\u2010dopa administration","volume":"217","author":"Hefti F.","year":"1981","journal-title":"J. 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