{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:52:07Z","timestamp":1791546727776,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T00:00:00Z","timestamp":1308268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:sec><jats:label\/><jats:p> <jats:italic>J. Neurochem.<\/jats:italic> (2011) <jats:bold>118<\/jats:bold>, 388\u2013398.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Carnitine palmitoyltransferase\u20101c (CPT1c) is a newly identified and poorly understood brain\u2010specific CPT1 homologue. Here, we have generated a new animal model that allows the conditional expression of CPT1c in a tissue specific and\/or temporal manner via Cre\u2010lox mediated recombination. Brain\u2010specific, exogenous expression of CPT1c was achieved by crossing transgenic CPT1c mice to Nestin\u2010Cre mice. The resulting double transgenic mice (CPT1c\u2010TgN) displayed severe growth retardation in the postnatal period with a stunted development at 2\u2003weeks of age. CPT1c\u2010TgN mice had a greater than 2.3\u2010fold reduction in brain weight. Even with this degree of microencephaly, CPT1c\u2010TgN mice were viable and fertile and exhibited normal post\u2010weaning growth. When fed a high fat diet CPT1c\u2010TgN mice were protected from weight gain and the difference in body weight between CPT1c\u2010TgN and control mice was further exaggerated. Conversely, low fat, high carbohydrate feeding partially reversed the body weight defects in CPT1c\u2010TgN mice. Analysis of total brain lipids of low fat fed mice revealed a depletion of total very long chain fatty acids in adult CPT1c\u2010TgN mice which was not evident in high fat fed CPT1c\u2010TgN mice. These data show that CPT1c can elicit profound effects on brain physiology and total fatty acid profiles, which can be modulated by the nutritional composition of the diet.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1471-4159.2011.07312.x","type":"journal-article","created":{"date-parts":[[2011,5,19]],"date-time":"2011-05-19T04:52:25Z","timestamp":1305780745000},"page":"388-398","source":"Crossref","is-referenced-by-count":29,"title":["Carnitine palmitoyltransferase\u20101c gain\u2010of\u2010function in the brain results in postnatal microencephaly"],"prefix":"10.1111","volume":"118","author":[{"given":"Amanda A.","family":"Reamy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael 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