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Such an interpretation is based on mapping of Lewy body and Lewy neurite pathology. Symptoms of the human disease are much widespread, which span from pre\u2010clinical non\u2010motor symptoms and clinical motor symptoms to cognitive discrepancies often seen in advanced stages. Existing symptomatic treatments further complicate with overt drug\u2010irresponsive symptoms. PD is better understood by assimilation of extranigral degenerative pathways with nigrostriatal degenerative mechanisms. The term \u2018extranigral\u2019 appeared first in the 1990s to more rigorously define the nigral pathology by process of elimination. However, as clinicians progressively identified PD symptoms unresponsive to the gold standard drug <jats:sc>l<\/jats:sc>\u2010DOPA, definitions of PD symptoms were redefined. Non\u2010motor symptoms prodromal to motor symptoms just as pre\u2010clinical to clinical, and conjointly emerged the concept of nigral versus extranigral degeneration in PD. While nigrostriatal degeneration is responsible for the neurobiological substrates of extrapyramydal motor features, extranigral degeneration corroborates a vast majority of other changes in discrete central, peripheral, and enteric nervous system nuclei, which together account for global symptoms of the human disease. As an extranigral site, spinal cord degeneration has also been implicated in PD progression. Interconnected to the upper CNS structures with descending and ascending pathways, spinal neurons participate in movement and sensory circuits, controlling movement and reflexes. Several clinical and <jats:italic>in vivo<\/jats:italic> studies have demonstrated signs of parkinsonism\u2010related degenerative processes in spinal cord, which led to recent consideration of spinal cord as an area of potential therapeutic target. In a nutshell, this review explores how the existing animal models can actually reflect the human disease in order to facilitate PD research. Evolution of extranigral degeneration studies has been succinctly revisited, followed by a survey on animal models in light of recent findings in clinical PD. Together, it may help to develop effective therapeutic strategies for PD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1471-4159.2011.07320.x","type":"journal-article","created":{"date-parts":[[2011,5,26]],"date-time":"2011-05-26T16:29:18Z","timestamp":1306427358000},"page":"326-338","source":"Crossref","is-referenced-by-count":17,"title":["Tracking extranigral degeneration in animal models of Parkinson\u2019s disease: quest for effective therapeutic strategies"],"prefix":"10.1111","volume":"118","author":[{"given":"Varduhi H.","family":"Knaryan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Supriti","family":"Samantaray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlene","family":"Le Gal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swapan K.","family":"Ray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naren L.","family":"Banik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,6,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2008.02.014"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1353-8020(09)70774-6"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)90534-7"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.2006.00727.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000086430"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00007758"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000312279.49272.9f"},{"key":"e_1_2_9_9_1","first-page":"15","article-title":"Nigral and extranigral pathology in Parkinson\u2019s disease","volume":"46","author":"Braak H.","year":"1995","journal-title":"J. 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