{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:13:39Z","timestamp":1790399619487,"version":"4.1.0"},"reference-count":57,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:sec><jats:label\/><jats:p><jats:italic>J. Neurochem.<\/jats:italic>(2011)<jats:bold>118<\/jats:bold>, 668\u2013676.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Neurotoxic doses of methamphetamine (METH) are known to cause depletions in striatal dopamine (DA) tissue content. However, the effects of METH\u2010induced insults on dopaminergic neurotransmission are not fully understood. Here, we employed fast\u2010scan cyclic voltammetry at a carbon\u2010fiber microelectrode in the anesthetized rat striatum to assess the effects of a neurotoxic regimen of METH on phasic and tonic modes of dopaminergic signaling and underlying mechanisms of DA release and uptake. Extracellular DA was electrically evoked by stimulation of the medial forebrain bundle mimicking tonic and phasic firing patterns for dopaminergic cells and was monitored simultaneously in both the dorsomedial and dorsolateral striatum. Kinetic analysis of evoked recordings determined parameters describing DA release and uptake. Striatal DA tissue content was quantified by high performance liquid chromatography with electrochemical detection. METH\u2010pretreatment (four doses of 7.5 or 10.0\u2003mg\/kg s.c.) induced DA depletions of \u223c 40% on average, which are reported in both striatal subregions. METH pre\u2010treatment significantly decreased the amplitude of signals evoked by phasic, but not tonic, stimulation. Parameters for DA release and uptake were also similarly reduced by \u223c 40%, consistent with effects on evoked phasic\u2010like responses and DA tissue content. Taken together, these results suggest that METH\u2010pretreatment selectively diminishes phasic, but not tonic, dopaminergic signaling in the dorsal striatum.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1471-4159.2011.07342.x","type":"journal-article","created":{"date-parts":[[2011,6,13]],"date-time":"2011-06-13T08:15:30Z","timestamp":1307952930000},"page":"668-676","source":"Crossref","is-referenced-by-count":32,"title":["Methamphetamine neurotoxicity decreases phasic, but not tonic, dopaminergic signaling in the rat striatum"],"prefix":"10.1111","volume":"118","author":[{"given":"Christopher D.","family":"Howard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen A.","family":"Keefe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Garris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Daberkow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)91318-B"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.02104.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0270(00)00372-1"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2000.00180.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(03)00038-9"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03033567"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac960347d"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2004.10.001"},{"key":"e_1_2_7_10_1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0022-3565(24)36396-7","article-title":"Decreases in evoked overflow of dopamine in rat striatum after neurotoxic doses of methamphetamine","volume":"280","author":"Cass W. 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